The potential for using germline genome editing (GGE) in humans has garnered a lot of attention, both for its scientific possibilities as well as for the ethical, legal, and social challenges it ignites. The ethical debate has focused primarily on the suggestions of using GGE to establish a pregnancy (i.e., to offer it in a clinical setting), which is, to date, illegal in many jurisdictions. The u

In this paper we address the question of how firms hedge in financial distress. Using hand-collected data from oil and gas producers, we show thatthe uniquecharacteristic of derivative portfolios in distressed firms is a strategythat involvessold put options. This is puzzling, considering that selling put options amounts to selling insurance, which creates a new liability that distressed firms seeIn this paper we address the question of how firms hedge in financial distress.Using hand-collected data from oil and gas producers, we show that the uniquecharacteristic of derivative portfolios in distressed firms is a strategy thatinvolves sold put options. This is puzzling, considering that selling put optionsamounts to selling insurance, which creates a new liability that distressed firmsseem

The microstructure of cortical bone is key for the tissue's high toughness and strength and efficient toughening mechanisms have been identified at the microscale, for example when propagating cracks interact with the osteonal microstructure. Finite element models have been proposed as suitable tools for analyzing the complex link between the local tissue structure and the fracture resistance of c

Background and aims: A vulnerable plaque is an atherosclerotic plaque that is rupture-prone with a higher risk to cause cardiovascular symptoms such as myocardial infarction or stroke. Mimecan or osteoglycin is a small leucine-rich proteoglycan, important for collagen fibrillogenesis, that has been implicated in atherosclerotic disease, yet the role of mimecan in human atherosclerotic disease rema

Background and aims: The aim of the study was to determine potential associations between endothelial dysfunction and arterial stiffness, measured by peripheral arterial tonometry, and coronary artery calcium score (CACS) assessed by computed tomography (CT). Methods and results: The BIG3 study is a prospective longitudinal, non-interventional, pulmonary-cardiovascular cohort study exploring the t

Int J Mol Med. 2001;8 Suppl 1:S5-107.

Nitrogen dioxide (NO2) is an important air pollutant with both environmental and epidemiological effects. The main aim of this study is to analyze spatial patterns and temporal trends in tropospheric NO2 concentrations globally using data from the satellite-based Ozone Monitoring Instrument (OMI). Additional aims are to compare the satellite data with ground-based observations, and to find the tim

Changing acceleration and forces are part of the excitement of a roller coaster ride. According to Newton's second law, F = ma, every part of our body must be exposed to a force to accelerate. Since our bodies are not symmetric, the direction of the force matters, and must be accounted for by ride designers. An additional complication is that not all parts of the body accelerate in the same way wh

Currently, policy makers in Sweden are considering updating building regulations with respect to daylight provision. Given this context, the present paper aims to provide insight on the level of compliance of residential spaces when tested against five daylight performance criteria. These included the criterion currently in force in Sweden, the two performance criteria set by European Standard EN1

PURPOSE: Physical activity (PA) has been linked to a reduced risk of type 2 diabetes by reducing weight and improving insulin sensitivity. We investigated whether PA is associated with a lower incidence of latent autoimmune diabetes in adults (LADA) and whether the association is modified by genotypes of human leukocyte antigen (HLA), transcription factor 7-like 2 (TCF7L2)-rs7903146, or the fat ma

The aim of this chapter is to show how ICT is used by employees to manage temporal and spatial availability for work and private matters. This sociomaterial practice is described in terms of ICT boundary work. The chapter is based on a case study into three multinational industrial companies in Sweden. Time diaries and semi-structured interviews with a sample of thirty-eight employees were used to