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A Proposal for the Performance, Classification, and Reporting of Lymph Node Fine-Needle Aspiration Cytopathology : The Sydney System

BACKGROUND: The evaluation of lymph nodes (LN) by fine-needle aspiration cytology (FNAC) is routinely used in many institutions but it is not uniformly accepted mainly because of the lack of guidelines and a cytopathological diagnostic classification. A committee of cytopathologists has developed a system of performance, classification, and reporting for LN-FNAC. METHODS: The committee members pre

2020 international consensus on ANCA testing beyond systemic vasculitis

This document follows up on a 2017 revised international consensus on anti-neutrophil cytoplasm antibodies (ANCA) testing in granulomatosis with polyangiitis and microscopic polyangiitis and focuses on the clinical and diagnostic value of ANCA detection in patients with connective tissue diseases, idiopathic interstitial pneumonia, autoimmune liver diseases, inflammatory bowel diseases, anti-glome

Early diagnosis is associated with improved clinical outcomes in benign esophageal perforation : an individual patient data meta-analysis

Background: Time of diagnosis (TOD) of benign esophageal perforation is regarded as an important risk factor for clinical outcome, although convincing evidence is lacking. The aim of this study is to assess whether time between onset of perforation and diagnosis is associated with clinical outcome in patients with iatrogenic esophageal perforation (IEP) and Boerhaave’s syndrome (BS). Methods: We s

Legal method and interpretation in international IP law : Pluralism or systemic coherence

This chapter focuses on legal interpretation, reflecting on policy options between pluralism and harmonisation in two separate levels: (1) the desirability of establishing, or not, further harmonisation of interpretative rules, criteria and praxis in IP law; (2) whether internal harmonisation or systemic coherence between different areas of law and regulation that affect the same object or legal f

Geographic clustering in evolutionary economic geography

Evolutionary economic geography (EEG) explains the spatial evolution of firms, industries, networks, cities and regions from elementary processes of the entry, growth, decline and exit of firms, and their locational behaviour. In an evolutionary approach to economic geography, one typically reasons from the historical processes that have led to particular spatial patterns such as uneven levels of

Handbook of research methods and applications in economic geography

The main purpose of this Handbook is to provide overviews and assessments of the state-of-the-art regarding research methods, approaches and applications central to economic geography. The chapters are written by distinguished researchers from a variety of scholarly traditions and with a background in different academic disciplines including economics, economic, human and cultural geography, and e

Introduction

Whatever type of human and economic activity we study, we find that it is not evenly spread out in space, but instead concentrated to a rather limited number of countries, regions and cities. What in particular is noticeable is that certain places, typically large city regions, host a large share of the wealth and knowledge generated in the modern world. Despite what we can read in the popular pre

Public procurement for innovation : Eu-SPRI forum on science, technology and innovation policy series

This book focuses on Public Procurement for Innovation. Public Procurement for Innovation is a specific demand-side innovation policy instrument. It occurs when a public organization places an order for a new or improved product to fulfill certain needs that cannot be met at the moment of the order. The book provides evidence of the potential benefits to public and private actors from the selectiv

The influence of fish consumption on serum n-3 polyunsaturated fatty acid (PUFA) concentrations in women of childbearing age : a randomised controlled trial (the iFish Study)

PURPOSE: Long-chain polyunsaturated fatty acids (LCPUFA) can be synthesised endogenously from linoleic acid (LA) and α-linolenic acid (ALA) in a pathway involving the fatty acid desaturase (FADS) genes. Endogenous synthesis is inefficient; therefore, dietary intake of preformed LCPUFA from their richest source of fish is preferred. This study investigated the effect of fish consumption on PUFA con

Factor VIII gene inversions in severe hemophilia A : Results of an international consortium study

Twenty-two molecular diagnostic laboratories from 14 countries participated in a consortium study to estimate the impact of Factor VIII gene inversions in severe hemophilia A. A total of 2,093 patients with severe hemophilia A were studied; of those, 740 (35%) had a type 1 (distal) factor VIII inversion, and 140 (7%) showed a type 2 (proximal) inversion. In 25 cases, the molecular analysis showed

Familial risks between Graves disease and Hashimoto thyroiditis and other autoimmune diseases in the population of Sweden

Genetic and family studies have indicated that Graves disease and Hashimoto thyroiditis have a heritable component which appears to be shared to some extend also with some other autoimmune diseases (AIDs). In the present nation-wide study we describe familial risk for Graves disease and Hashimoto thyroiditis identified from the Swedish Hospital Discharge Register (years 1964 through 2012) and the

Moving Targets: On reducing public responsibilities through re-categorising homeless people and refugees

Categorising people and housing situations is unavoidable in research and national and local statistics on homelessness, as well as in regulating and planning for interventions and supply and allocation of suitable accommodation. Despite different motives and original functions, however, these categories and the use of them are influenced by the political discourse, especially when they travel froCategorising people and housing situations is unavoidable in research and national and local statistics on homelessness, as well as in regulating and planning for interventions and supply and allocation of suitable accommodation. Despite different motives and original functions, however, these categories and the use of them are influenced by the political discourse, especially when they travel fro

Techno-Economic Evaluation of Biorefineries Based on Low-Value Feedstocks Using the BioSTEAM Software: A Case Study for Animal Bedding

Biofuels are still too costly to compete in the energy market and it has been suggested that low-value feedstocks could provide an opportunity for the production of low-cost biofuels; however, the lower quality of these feedstocks requires the introduction of a conditioning step in the biorefinery process. The aim of this study was to evaluate whether feedstock savings cover the cost of conditioni

Who's Homeless and Whose Homeless?

What does the persistent construction of ‘the homeless’ and the revitalised term ‘our homeless’ include, imply, and ex- clude in Swedish political debate? And how is it politically and morally related to other houseless groups in the country? These questions are approached through an analysis of minutes from the Swedish Parliament 2015–2019. Inspired by Simmel’s (1908/1965) definition of ‘the poor