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Accelerating target deconvolution for therapeutic antibody candidates using highly parallelized genome editing

Therapeutic antibodies are transforming the treatment of cancer and autoimmune diseases. Today, a key challenge is finding antibodies against new targets. Phenotypic discovery promises to achieve this by enabling discovery of antibodies with therapeutic potential without specifying the molecular target a priori. Yet, deconvoluting the targets of phenotypically discovered antibodies remains a bottl

Meaning-making in a context of climate change : Supporting agency and political engagement

Responding effectively to climate change requires an understanding of what shapes people’s individual and collective sense of agency and responsibility towards the future. It also requires transforming this understanding into political engagement to support systems change. Based on a national representative survey in Sweden (N = 1,237), this research uses the novel SenseMaker methodology to look i

FashioNordic : Folkcostume as Performance of Genealogy and Place

This article elaborates on the embodiment of heritage via dressing practices in several rural and urban Nordic communities in the United States. Getting dressed is a shared human practice that we engage in and repeat most days, and for special occasions, traditional dress, or folk costume, comes into particular focus. I approach dressing in folk costume as a "situated embodied practice," a mode of

Urban Navigation with LTE using a Large Antenna Array and Machine Learning

Channel fingerprinting entails associating a point in space with measured properties of a received wireless signal. If the propagation environment for that point in space remains reasonably static with time, then a receiver with no knowledge of its own position experiencing a similar channel in the future might reasonably infer proximity to the original surveyed point. In this article, measurement

Search for Dark Matter in events with missing transverse momentum and a Higgs boson decaying into bottom quarks with the ATLAS detector

Many astrophysical observations indicate the existence Dark Matter, which is not predicted by the Standard Model (SM) of particle physics. Many theories beyond the Standard Model (BSM) predict new heavy particles called WIMPs (Weakly Interacting Massive Particles). One way to search for WIMP dark matter is through its pair-production in collider experiments. A possible signature, in this case, is

Impact of Sociodemographic Factors on Use of Formal Social Services in an Older Swedish Population

Background: In Sweden, societal support for older people is the responsibility of the municipalities. However, due to Sweden’s current aging-in-place policy for older people, there is a need to assess how the use of such services varies based on sociodemographic factors. The aim of this study was to describe the use of different forms of social services and institutional long-term care (ILTC) in a

Sociodemographic Variations in the Availability of Urban Green Spaces in an Older Swedish Population

Urban green spaces (UGS) can have a positive impact on health and thereby potentially ease the strain on the health care system. However, the availability and benefits seem to vary between different sociodemographic groups. The aim of this study was to investigate associations between sociodemographic factors and availability to UGS among people aged 65 years or older. Data on sociodemographic var

Visions of a City for All : Resources, Choices and Factors Supporting and Impeding Universal Design in the Urban Development Process

Despite laws, policies and visions to create cities and societies for all, barriers still exclude persons with disabilities from using buildings and public places. Our study aimed to identify choices made during the urban development process that include or exclude users in the built environment; how and when these choices arise during the process; and what is needed to implement universal design

Evaluating Transformation - what can we learn from the literature?

The last decade’s rise of the so-called “third frame” (or third generation) of Transformative Innovation Policies (TIP) has shifted focus of research and innovation investments from economic growth and competitiveness to also tackling societal challenges and generating broader environmental and societal impact. The evolution in rationale and aims for policy action also implies a need to adapt and The last decade’s rise of the so-called “third frame” (or third generation) of Transformative Innovation Policies (TIP) has shifted focus of research and innovation investments from economic growth and competitiveness to also tackling societal challenges and generating broader environmental and societal impact. The evolution in rationale and aims for policy action also implies a need to adapt and