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Eliminating line of sight in elliptic guides using gravitational curving

Eliminating fast neutrons (lambda < 0.5 angstrom) by removing direct line of sight between the source and the target sample is a well established technique. This can be done with little loss of transmission for a straight neutron guide by horizontal curving. With an elliptic guide shape, however, curving the guide would result in a breakdown of the geometrical focusing mechanism inherent to the el

Common variants at 30 loci contribute to polygenic dyslipidemia

Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic basis of these traits, we conducted genome-wide association screens in 19,840 individuals and replication in up to 20,623 individuals. We identified 30 distinct loci associated with lipoprotein concentrations (each

Absolute core-level binding energy shifts between atom and solid : The Born-Haber cycle revisited for free nanoscale metal clusters

Abstract in Undetermined Core-level binding energy shifts between the free atomand corresponding large clusters, the latter closely approximating the infinite solid, have been experimentally derived for several elemental metals. The cluster core-level binding energies in question have been determined relative to the vacuum level using synchrotron-based photoelectron spectroscopy. As expected, the

Recent advances in the characterization of HIV-1 neutralization assays for standardized evaluation of the antibody response to infection and vaccination

In AIDS vaccine development the pendulum has swung towards a renewed emphasis on the potential role for neutralizing antibodies in a successful global vaccine. It is recognized that vaccine-induced antibody performance, as assessed in the available neutralization assays, may well serve as a "gatekeeper" for HIV-1 subunit vaccine prioritization and advancement. As a result, development of a standar

Paradoxes of authentic leadership: Leader identity struggles

Using in-depth interview material, this article explores the socially constructed and locally mediated nature of authentic leadership. The findings illustrate an irony of authentic leadership: while leaders claim that it is their true and natural selves that make them good leaders; simultaneously, they must restrain their claimed authenticity in order to be perceived as good leaders. This generate

The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation

Chronic inflammation has been strongly associated with tumor progression, but the underlying mechanisms remain elusive. Here we demonstrate that E3 ligase Itch and deubiquitinase Cyld formed a complex via interaction through 'WW-PPXY' motifs. The Itch-Cyld complex sequentially cleaved Lys63-linked ubiquitin chains and catalyzed Lys48-linked ubiquitination on the kinase Tak1 to terminate inflammato

The Ethnic Employment and Income Gap in Sweden: Is Skill or Labor Market Discrimination the Explanation?

This study uses a cognitive test score, the Swedish Military Enlistment test taken at age 18, to identify whether the ethnic employment and income gap in Sweden is caused by a pre-market skill gap and/or ethnic discrimination. The employment gap and income gap are estimated for males born in Sweden with different ethnic backgrounds: their parents were born in Sweden or in southern Europe or outsid

Recent Advances in Plasmonic Sensors

Plasmonic sensing has been an important multidisciplinary research field and has been extensively used in detection of trace molecules in chemistry and biology. The sensing techniques are typically based on surface-enhanced spectroscopies and surface plasmon resonances (SPRs). This review article deals with some recent advances in surface-enhanced Raman scattering (SERS) sensors and SPR sensors us

A comparative study of the reactivity of the lightly stabilized cluster [Os-3(CO)(8){mu(3)-Ph2PCH2P(Ph)C6H4}(mu-H)] towards tri(2-thienyl)-, tri(2-furyl)- and triphenyl-phosphine

Reactions of the lightly stabilized triosmium cluster [Os-3(CO)(8){mu(3)-Ph2PCH2P(Ph)C6H4}(mu-H)] with tri(2-thienyl)phosphine (PTh3) and tri(2-furyl)phosphine (PFu(3)) are described and compared to analogous reactions with PPh3. At room temperature, a number of products are isolated: [Os-3(CO)(10)(mu-dppm)] from CO addition, [Os-3(CO)(8)(PR3){mu(3)-Ph2PCH2P(Ph)C6H4}(mu-H)] from phosphine addition

The variability of processes involved in transgene dispersal-case studies from Brassica and related genera

Background, aim, and scope We strive to predict consequences of genetically modified plants (GMPs) being cultivated openly in the environment, as human and animal health, biodiversity, agricultural practise and farmers' economy could be affected. Therefore, it is unfortunate that the risk assessment of GMPs is burdened by uncertainty. One of the reasons for the uncertainty is that the GMPs are int

Multiparticle azimuthal correlations in p-Pb and Pb-Pb collisions at the CERN Large Hadron Collider

Measurements of multiparticle azimuthal correlations (cumulants) for charged particles in p-Pb at root s(NN) = 5.02 TeV and Pb-Pb at root s(NN) = 2.76 TeV collisions are presented. They help address the question of whether there is evidence for global, flowlike, azimuthal correlations in the p-Pb system. Comparisons are made to measurements from the larger Pb-Pb system, where such evidence is esta

Prediction and experimental verification of the cutting forces in gear form milling

In this paper, a mathematical model is presented by which the cutting forces in gear form milling process are predicted using the mechanistic approach. To use this approach, a detailed description of the chip geometry is needed. Eccentricity and run-out tool errors are considered, which is of great importance as the chip thickness will by these errors vary for the subsequent cuts. The chip geometr

The size of the disease relevant IgE antibody fraction in relation to 'total-IgE' predicts the efficacy of anti-IgE (Xolair (R)) treatment

Background: Some patients with allergic asthma treated with anti-IgE (Xolair (R)) do not become symptom free. Better criteria for response assessment than allergy skin tests or IgE determination are needed. The impact of the size of the disease relevant allergen-specific IgE antibody fraction, i.e. the percentage of IgE antibody of total IgE, was evaluated in cat allergic patients treated with the

Biogeochemical control of the coupled CO2-O2 system of the Baltic Sea: A review of the results of Baltic-C

Past, present, and possible future changes in the Baltic Sea acid-base and oxygen balances were studied using different numerical experiments and a catchment-sea model system in several scenarios including business as usual, medium scenario, and the Baltic Sea Action Plan. New CO2 partial pressure data provided guidance for improving the marine biogeochemical model. Continuous CO2 and nutrient mea