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Improvement in diagnostic quality of structural and angiographic MRI of the brain using motion correction with interleaved, volumetric navigators

Introduction Subject movements lead to severe artifacts in magnetic resonance (MR) brain imaging. In this study we evaluate the diagnostic image quality in T1-weighted, T2-weighted, and timeof-flight angiographic MR sequences when using a flexible, navigator-based prospective motion correction system (iMOCO). Methods Five healthy volunteers were scanned during different movement scenarios with and

Metadata filtering for user-friendly centralized biometric authentication

While biometric authentication for commercial use so far mainly has been used for local device unlock use cases, there are great opportunities for using it also for central authentication such as for remote login. However, many current biometric sensors like for instance mobile fingerprint sensors have too large false acceptance rate (FAR) not allowing them, for security reasons, to be used in lar

MRI morphology of the hippocampus in drug-resistant temporal lobe epilepsy: shape inflation of left hippocampus and correlation of right-sided hippocampal volume and shape with visuospatial function in patients with right-sided TLE

We sought to quantify the morphology in vivo of hippocampi in patients with drug resistant temporal lobe epilepsy (TLE) via magnetic resonance imaging (MRI), prior to temporal lobe resection, and the correlation of surface-based shape analysis of morphology and clinical cognitive function.Thirty patients with drug-resistant TLE and twenty healthy controls underwent clinical neuropsychological test

Worldwide comparison of survival from childhood leukaemia for 1995-2009, by subtype, age, and sex (CONCORD-2) : a population-based study of individual data for 89 828 children from 198 registries in 53 countries

BACKGROUND: Global inequalities in access to health care are reflected in differences in cancer survival. The CONCORD programme was designed to assess worldwide differences and trends in population-based cancer survival. In this population-based study, we aimed to estimate survival inequalities globally for several subtypes of childhood leukaemia.METHODS: Cancer registries participating in CONCORD

Origins of the Tājika System of Astrological Aspects and Dignities

The astrological doctrines of aspects and planetary dignities found in the authoritative texts of the Tājika (Sanskritized Perso-Arabic) school are examined with respect to their origins and historical development, with particular emphasis on Balabhadra’s encyclopaedic Hāyanaratna (1649) and its quotations from the perhaps earliest work of the school, Samarasiṃha’s Tājikaśāstra (thirteenth century

Notes on Some Sanskrit Astrological Authors

This paper supplements and corrects the information given in the works of David Pingree regarding four major authors on Tājika or Sanskritized Perso-Arabic astrology from the fourteenth to the seventeenth century: Tejaḥsiṃha, Yādavasūri, Bālakṛṣṇa and Balabhadra. It further contributes information on a fifth such author, Tuka, not discussed by Pingree.

The Sanskrit and Arabic Sources of the Praśnatantra Attributed to Nīlakaṇṭha

The highly popular Praśnatantra attributed to Nīlakaṇṭha of Kāśī (fl. late 16th century) and sometimes regarded as the third volume of his Tājikanīlakaṇṭhī is shown to depend for its basic structure on an abridged Sanskrit version of the Kitāb fi l-masāʾil wa-l-aḥkām by Sahl ibn Bishr (early 9th century), apparently authored by Samarasiṃha in the 13th century, to which quotations primarily from Sa

Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs

Serine hydroxymethyltransferase (SHMT) is the major source of 1-carbon units required for nucleotide synthesis. Humans have cytosolic (SHMT1) and mitochondrial (SHMT2) isoforms, which are upregulated in numerous cancers, making the enzyme an attractive drug target. Here, we show that the antifolates lometrexol and pemetrexed are inhibitors of SHMT2 and solve the first SHMT2-antifolate structures.

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Beslutsfattare bör inse betydelsen av butikers vara eller inte vara för samhällets utveckling innan det är för sent, skriver Karin M Ekström, professor i företagsekonomi, och Håkan Jönsson, docent i etnologi.