Purpose: The aim of this study was to evaluate ERK phosphorylation as a stromal biomarker for breast cancer prognosis and tamoxifen treatment prediction within a randomized tamoxifen trial. Patients and Methods: Tissue microarrays of two breast cancer cohorts including in total 743 invasive breast cancer samples were analyzed for ERK phosphorylation (pERK) and smooth muscle actin-alpha expression

This thesis deals with event-based control and estimation strategies, motivated by certain bottlenecks in the control loop. Two kinds of implementation constraints are considered: closing one or several control loops over a data network, and sensors that report measurements only as intervals (e.g. with quantization). The proposed strategies depend critically on _events_, when a data packet is sent

Recension av Owen Matthews; Stalins barn. Tre generationer av kärlek och krig.

The feasibility of using pressure-sensitive paint for oxygen concentration measurements in low-temperature combustion environments has been investigated and applied to slow combustion processes. In addition, the temperature limitation for this application was studied. A Nd:YAG laser system, a PMT and fiber-optics were used for developing a compact probe for oxygen measurements. The lifetime sensit

A review of literature related to fire evacuation in high-rise buildings was carried out with the following objectives, (1) to identify the key behavioural factors affecting the performance of people during a fire in a high-rise building, the singularities associated to this type of buildings and areas of future research; (2) to review the procedures and strategies currently adopted in high-rise b

The poems of Frans G Bengtsson are analyzed first as produced from the viewpoint of Schopenhauer's radical pessimism,and Bengtsson´s serious illness. The poems formal and thematic characters are scrutinized: the formal excellence is conceived as a manifestation of a kantian aesthetic, also as a mark of Bengtsson's extreme objectivism, his inclination towards the factual. The most dominant theme in

Event-by-event fluctuations of the mean transverse momentum of charged particles produced in pp collisions at root s = 0.9, 2.76 and 7 TeV, and Pb-Pb collisions at root S-NN = 2.76 TeV are studied as a function of the charged-particle multiplicity using the ALICE detector at the LHC. Dynamical fluctuations indicative of correlated particle emission are observed in all systems. The results in pp co

FK506-binding protein-like (FKBPL) has established roles as an anti-tumor protein, with a therapeutic peptide based on this protein, ALM201, shortly entering phase I/II clinical trials. Here, we evaluated FKBPL's prognostic ability in primary breast cancer tissue, represented on tissue microarrays (TMA) from 3277 women recruited into five independent retrospective studies, using immunohistochemist

Vårt syfte med denna rapport är att diskutera drivmedel från ett brett perspektiv ur hållbarhetssynpunkt. Biodrivmedel och el analyseras och jämförs med fossila drivmedel. Vår målsättning är att försöka peka ut under vilka förutsättningar som drivmedel kan anses försvarbara ur hållbarhetssynpunkt och vilka system som vi bör utveckla respektive vilka system som vi bör undvika. En övergripande sluts

delta C-13 values of 142 samples from the Manitoulin Formation and subjacent strata collected from 14 exposures and two drill-cores on Manitoulin Island, Bruce Peninsula, and the region south of Georgian Bay suggest that the Manitoulin Formation is latest Ordovician (Hirnantian) rather than earliest Silurian in age. A delta C-13 excursion identified as the Hirnantian isotope carbon excursion (HICE

Background: Musculoskeletal disorders are very common and almost inevitable in an individual's lifetime. Enabling self-management and allowing the individual to take responsibility for care is stated as desired in the management of these disorders, but this may be asking more than people can generally manage. A willingness among people to take responsibility for musculoskeletal disorders and not p

Communicative abilities and opportunities are affected by ventilator care. The purpose of this case study was to investigate both a nurse's and a ventilator-supported patient's experiences of communication during ventilator care, with the overall aim of contributing to increased knowledge and awareness of issues related to communication with a ventilator-supported patient. An explorative/descripti

BACKGROUND: Mechanisms regulating the ABO gene are unclear, especially in the hematopoietic compartment. The number of 43-bp repeats in the CBF/NF-Y-binding enhancer region is considered to have a major influence on transcription. STUDY DESIGN AND METHODS: Transcript levels in peripheral blood and in erythropoietic culture of CD34+ cells from marrow donors were measured with TaqMan assays. The 5'-

Objective To investigate if the prediction of malignant adnexal masses can be improved by considering different ultrasound-based subgroups of tumors and constructing a scoring system for each subgroup instead of using a risk estimation model applicable to all tumors. Methods We used a multicenter database of 1573 patients with at least one persistent adnexal mass. The masses were categorized into

In this paper, we consider the bootstrap procedure for the augmented Dickey-Fuller (ADF) unit root test by implementing the modified divergence information criterion (MDIC, Mantalos et al. [An improved divergence information criterion for the determination of the order of an AR process, Commun. Statist. Comput. Simul. 39(5) (2010a), pp. 865-879; Forecasting ARMA models: A comparative study of info

The aim is to review a patented method and apparatus for treating tumor diseases (cancer) with a combination of ionizing radiation and pulsed electric fields, that might open a new regime of radiation therapy fractionation with a short intensive treatment with high radiation dose fractions combined with pulsed electric fields. Sub-optimal radiation treatment was administered separately or in combi

Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and pro