Many lines of evidence support that β-amyloid (Aβ) peptides play an important role in Alzheimer's disease (AD), the most common cause of dementia. But despite much effort the molecular mechanisms of how Aβ contributes to AD remain unclear. While Aβ is generated from its precursor protein throughout life, the peptide is best known as the main component of amyloid plaques, the neuropathological hall

BACKGROUND: Tamoxifen has been associated with an increased risk of stroke. There is, however, little information on the effect in the post-treatment period. Using data from the Swedish Breast Cancer Group adjuvant trial of 5 vs 2 years of tamoxifen treatment, we now report both short-term and long-term effects on morbidity as well as mortality because of cerebrovascular disease. METHODS: Data fro

In this work, the water extraction and particle formation on-line (WEPO) process has been used to obtain dry antioxidant powder from rosemary leaves. This process includes pressurized hot water extraction (PHWE) and on-line drying of the extracts in one step. Based on previous works, water extraction at 200 degrees C was selected to achieve the maximum antioxidant activity while water flow rate wa

The present study investigated the effects of land-use abandonment on the soil decomposer community of two grazed Mediterranean ecosystems (an annual grassland with scattered holm oaks and a low-density shrubland). To test the influence of grazing abandonment, a set of plots within each site were fenced and kept undisturbed during 4-5 years, during which above-ground plant community structure was

P>Carbon of terrestrial origin often makes up a significant share of consumer biomass in unproductive lake ecosystems. However, the mechanisms for terrestrial support of lake secondary production are largely unclear. By using a modelling approach, we show that terrestrial export of dissolved labile low molecular weight carbon (LMWC) compounds supported 80% (34-95%), 54% (19-90%) and 23% (7-45%) of

The paper studies the effects of market discipline by creditors and ownership structure on banks' risk taking in the presence of partial deposit insurance. An agency-cost model explains how the effects of creditor discipline and shareholder control arc interdependent, the non-monotonic effect of shareholder control, and the role of leverage. Panel regressions on several hundred banks worldwide 199

This paper represents the opinion of a group of researchers and clinicians with an established interest in poststroke care and is based on the recognised need for long-term care following stroke, especially in view of the global increase of disability due to stroke. Among the more frequent long-term complications following stroke are spasticity-related disabilities. Although spasticity alone occur

Abstract is not available

Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease with chronic or episodic inflammation in many different organ systems, activation of leukocytes and production of pro-inflammatory cytokines. The heterodimer of the cytosolic calcium-binding proteins S100A8 and S100A9 (S100A8/A9) is secreted by activated polymorphonuclear neutrophils (PMNs) and monocytes and serves as a seru

Abstract Objective. The reference standard for lymph-node staging in prostate cancer is currently an extended pelvic lymph-node dissection (ePLND), which detects most, but not all, regional lymph-node metastases. As an alternative to ePLND, sentinel-node dissection with preoperative isotope injection and imaging has been reported. The objective was to determine whether intraoperative sentinel-node

Introduction: The inspiratory flow pattern influences CO2 elimination by affecting the time the tidal volume remains resident in alveoli. This time is expressed in terms of mean distribution time (MDT), which is the time available for distribution and diffusion of inspired tidal gas within resident alveolar gas. In healthy and sick pigs, abrupt cessation of inspiratory flow (that is, high end-insp

Aim This study investigates inter-annual variability in burnt area in southern Africa and the extent to which climate is responsible for this variation. We compare data from long-term field sites across the region with remotely sensed burnt area data to test whether it is possible to develop a general model. Location Africa south of the equator. Methods Linear mixed effects models were used to det

The amyloid cascade hypothesis on the pathogenesis of Alzheimer's disease (AD) states that amyloid beta (A beta) accumulation in the brain is a key factor that initiates the neurodegenerative process. A beta is generated from amyloid precursor protein (APP) through sequential cleavages by BACE1 (the major beta-secretase in the brain) and gamma-secretase. The purpose of this study was to characteri

A QM/MM investigation of the active-ready (Hox) form of [FeFe]-hydrogenase from D. desulfuricans, in which the electronic properties of all Fe-S clusters (H, F and F') have been simultaneously described using DFT, was carried out with the aim of disclosing a possible interplay between the H-cluster and the accessory iron-sulfur clusters in the initial steps of the catalytic process leading to H2 f

This paper analyses the potential, barriers and limitations for regional innovation policy to facilitate industrial renewal in old industrial regions. It draws on a case analysis of the policy programme ‘Biorefinery of the Future’ geared to promote renewal of the forest industry in Northern Sweden. It is shown that infusion of radical emergent technology is necessary for new regional path developm

The marsh zones of Sunderban coast were examined for modern benthic marsh foraminiferal assemblages and correlated with the typical mangrove vegetation. A total of 14 genera of foraminifera and 8 genera of mangrove plants were recorded from the region. The assemblage is characterised by agglutinated and calcareous foraminifera. The high, middle and low marshes are identified on the basis of positi

This paper provides an empirical analysis of the impact of tax differentials and agglomeration economies on foreign direct investment (FDI). The paper departs from most previous work on FDI and tax competition in a number of ways. First, it incorporates several measures of agglomeration in order to investigate whether agglomeration economies mitigate the downward spiral in tax rates. As the streng

The concept ‘adult education’ is usually restricted to organisations where the cultural and societal development of the participants is emphasised. The title of this paper suggests that vocational education and training, too, has been important in adult education. In this paper, the opportunities for adults in Sweden in vocational education and training in the period 1918-1968 are explored with a