Sustainability challenges are defined by their complex and multifaceted interactions between nature and society and contention as to how and where to direct problem-solving efforts. This chapter presents four different approaches that exist for framing sustainability challenge areas that are introduced and worked with by students in LUMES International Master Programme in Environmental Studies and

SNOW 3G is a stream cipher designed in 2006 by ETSI/SAGE, serving in 3GPP as one of the standard algorithms for data confidentiality and integrity protection. It is also included in the 4G LTE standard. In this paper we derive vectorized linear approximations of the finite state machine in SNOW3G. In particular,we show one 24-bit approximation with a bias around 2−37 and one byte-oriented approxim

Patients with chemotherapy-induced bone marrow aplasia often develop severe thrombocytopenia which requires platelet transfusion. However, up to 25% of the patients show a less than adequate response to the transfusion. This phenomenon is called platelet refractoriness and is associated with increased morbidity and mortality as well as longer hospital stays and increased costs.It is well documente

BACKGROUND/AIMS: Metabolically healthy obesity (MHO) remains controversial, since the underlying mechanisms behind this phenotype remain unclear. We aimed to investigate the characteristics of MHO, as well as prospective risks.METHOD: A cross-sectional analysis was carried out in a subsample of 3812 obese subjects selected from the Malmo diet cancer study (n=28,403). Subjects with MHO (n=1182) wer

BACKGROUND: Spatial epidemiological analyses primarily depend on spatially-indexed medical records. Some countries have devised ways of capturing patient-specific spatial details using ZIP codes, postcodes or personal numbers, which are geocoded. However, for most resource-constrained African countries, the absence of a means to capture patient resident location as well as inexistence of spatial d

This study concerns the evolution of morphological patterns that often arise on the interface of bi-material, so called metal precipitate phase, due to the instability of the interfaces. The instability leads to growth or retraction of small perturbation, which may determine the formation of a variety of morphological patterns initially arising on surfaces of growing precipitates at small length s

FN:s konvention om barnets rättigheter är en internationell överenskommelse, beslutad 1989, som fått stort inflytande på barnpolitik och lagstiftning i många av världens länder. Vi presenterar här några erfarenheter från ett mångårigt utbild-ningsprogram om barns rättigheter inom utbildningssektorn, finansierat av Sida och genomfört av Lunds universitet. Författarna har medverkat i programmet som

Systemic sclerosis (SSc) is an autoimmune disease that shows one of the highest mortality rates among rheumatic diseases. We perform a large genome-wide association study (GWAS), and meta-analysis with previous GWASs, in 26,679 individuals and identify 27 independent genome-wide associated signals, including 13 new risk loci. The novel associations nearly double the number of genome-wide hits repo

The extracellular matrix (ECM) is a major regulator of homeostasis and disease, yet the 3D structure of the ECM remains poorly understood because of limitations in ECM visualization. We recently developed an ECM-specialized method termed in situ decellularization of tissues (ISDoT) to isolate native 3D ECM scaffolds from whole organs in which ECM structure and composition are preserved. Here, we p

Alternative reproductive tactics (ARTs) have improved our understanding of the evolution of adaptive variation; for instance, their study has led us to understand that the best phenotype (e.g. large and flashy) for a tactic that uses one mating behavior (e.g. court females) is often not the best phenotype (e.g. small and inconspicuous) for a tactic that uses a different mating behavior (e.g. chase

Background and Purpose- Extracellular matrix proteins are important in atherosclerotic disease by influencing plaque stability and cellular behavior but also by regulating inflammation. COMP (cartilage oligomeric matrix protein) is present in healthy human arteries and expressed by smooth muscle cells. A recent study showed that transplantation of COMP-deficient bone marrow to apoE-/- mice increas

We present an architecture for distributed, heterogeneous systems where there is a clear separation of concerns for Computation, Coordination, Configuration. The computation part is often implemented in traditional programming code, and packaged as services. The other concerns might need to be addressed much later and by other people in separate organisations, or even by end users. In this paper w

Background: Primary indication for catheter ablation of atrial fibrillation (AF) is to reduce symptoms and improve health-related quality of life (HRQoL). There are data showing differences between the genders and between younger and older patients. To evaluate this, we studied a large Scandinavian cohort of patients referred for catheter ablation of AF. Methods: Consecutive patients filled out th

Recent warming in the Arctic, which has been amplified during the winter1–3, greatly enhances microbial decomposition of soil organic matter and subsequent release of carbon dioxide (CO2)4. However, the amount of CO2 released in winter is not known and has not been well represented by ecosystem models or empirically based estimates5,6. Here we synthesize regional in situ observations of CO2 flux f

Background: Medical advancements have resulted in better survival and life expectancy among those with spina bifida, but a significantly increased risk of perinatal and postnatal mortality for individuals with spina bifida remains. Objectives: To examine stillbirth and infant and child mortality among those affected by spina bifida using data from multiple countries. Methods: We conducted an obser