Protein-ligand-exchange kinetics determines the duration of biochemical signals and consequently plays an important role in drug design. Binding studies commonly require solubilization of designed ligands in solvents such as dimethyl sulfoxide (DMSO), resulting in residual amounts of DMSO following titration of solubilized ligands into aqueous protein samples. Therefore, it is critical to establis

High fidelity gridded temperature datasets are difficult to obtain for areas with sparse coverage of meteorological stations given that sparsity of stations is known to introduce uncertainty in the interpolation of climatic variables generally. Inspired by their potential for optimal results especially for small sample datasets, we assessed and compared the accuracy of interpolation results of Emp

Allt våldsammare deportationer. Fler oskyldiga människor i fängsligt förvar. Fler svårt sjuka barn som skickas till länder där det är högst osäkert om de kan få vård. Ett stigande antal föräldrar som tar med sig sina barn på sjöodugliga båtar över medelhavet för att undvika mångårig separation. En växande mängd ungdomar som lever ett liv i papperslöshetens skuggsamhälle. Detta är några sannolika f

This article presents a study of the contradiction between the rhetoric of return, stressing that rejected asylum seekers should leave the country, and the reality of how migrants end up as legally stranded, in Sweden. Through a qualitative analysis of; 25 decisions by the Swedish Migration Agency, an internal quality report about the legal application, and the documentation in two complete indivi

This article is based on a two-year research project, ‘The Best Interests of the Child – From Words to Deeds’. The aim of the article is to present and highlight findings on the discrepancy between the policy of the ‘best interests’ principle and its implementation in the asylum application procedures at the Swedish Migration Board. There is a clear ambition to implement the principle of the best

Introduction: Etiological diagnosis of neurocognitive disorders of middle-old age relies on biomarkers, although evidence for their rational use is incomplete. A European task force is defining a diagnostic workflow where expert experience fills evidence gaps for biomarker validity and prioritization. We report methodology and preliminary results. Methods: Using a Delphi consensus method supported

Cultural and religious diversity are contested topics in Swedish publicdebate. This chapter analyses how theradio programmeMänniskor och tro(Peo-ple and belief)enables and structuresthe actors and issues that become heard inthis debate, particularlywith regardtoIslam and Muslims. The programme aimsto present an alternative to the dominantnegative media discourses by equallyrepresenting Christianit

Dual-fuel (DF) operation with methanol-diesel allows to reduce CO2 emissions, increase efficiency and decrease NOx and soot. This paper describes the experimental results with methanol-water (MeOH-W) blends as a fuel, and has three objectives: (1) whether water acts as a knock suppressant, enabling higher diesel substitution ratios, (2) if water can be a measure to control engine-out NOx emissions