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CGRP and CGRP receptor distribution in the human trigeminal ganglion
Effects of slash retention and wood ash addition on fine root biomass and production and fungal mycelium in a Norway spruce stand in SW Sweden
In the study reported here we examined the short-term effects (1-3 years) of slash retention (SR) and the long-term effects (13-15 years) of wood-ash application (A) on fine roots and mycorrhizae in a 40-year-old Norway spruce forest in southwest Sweden. Soil cores were used to obtain estimates of the biomass (g m(-2)) of roots in three diameter classes (< 0.5, 0.5-1 and 1-2 mm), root length densi
I tillvarons gränsland : perspektiv på kroppen mellan liv och död
Resolution of leucocyte-mediated mucosal diseases. A novel in vivo paradigm for drug development
Removal of disease-driving inflammatory leucocytes is central to resolution of inflammation. The current pharmacological dogma teaches leucocyte elimination through apoptosis followed by phagocytosis. However, actual resolving roles of apoptotic-phagocytic processes have been difficult to demonstrate in the major diseases that are characterized by mucosal tissue inflammation. Many current in vivo
Synthesis, structure, magnetic property and self-assembly of two double end-on azide bridged ferromagnetic nickel(II) complexes with distinct bidentate blocking ligands: A combined experimental and theoretical study
Two centrosymmetric dinuclear nickel(II) complexes, [Ni-2(dmpn)(2)(hap)(2)(mu(1,1)-N-3)(2)] and [Ni-2(dmpn)(2)(hap)(2)(mu(1,1)-N-3)(2)], (dmpn=N,N-dimethyl-1,3-diaminopropane and Hhap = 2-hydroxyacetophenone, Hhan = 1-hydroxy-2-acetonaphthone) have been synthesized and characterized. Single crystal X-ray diffraction analyses confirm the structures of one of the tridentate Schiff bases used and bot
Imprinted polymer beads enabling direct and selective molecular separation in water
In this paper, we describe the synthesis of water-compatible Molecularly Imprinted Polymer (MIP) microspheres by nanoparticle-stabilized emulsion (Pickering emulsion) polymerization. During the polymerization, the amount of the porogen used not only affected the stability of the Pickering emulsion but also the specific molecular recognition of the obtained MIP microspheres. Under optimized conditi
Detection of fixations and smooth pursuit movements in high-speed eye-tracking data
A novel algorithm for the detection of fixations and smooth pursuit movements in high-speed eye-tracking data is proposed, which uses a three-stage procedure to divide the intersaccadic intervals intoa sequence of fixation and smooth pursuit events. The first stage performs a preliminary segmentationwhile the latter two stages evaluate the characteristics of each such segment and reorganize the pr
From Stagnation to Sustained Growth: The Role of Female Empowerment
This paper explores the role of gender equality over a long-run economic and demographic development path of industrialized countries. Our unified cliometric growth model of female empowerment suggests that changes in gender relations are a key ingredient of economic development. The economy evolves from a Malthusian regime–with slow technological progress, low income and low fertility–to a Modern
Neoadjuvant/Downstaging Radiochemotherapy in Marginally Resectable Pancreatic Cancer
Pancreatic cancer is a challenging disease due to the low resection rate at the time of initial diagnosis. A relatively new classification of marginally resectable pancreatic cancer has emerged and there is some evidence that this subgroup of patients may benefit from neoadjuvant radiochemotherapy. The first major definition of marginally resectable pancreatic cancer was made at M. D. Anderson Can
Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis
Background To investigate potential cardiovascular and other effects of long-term pharmacological interleukin 1 (IL-1) inhibition, we studied genetic variants that produce inhibition of IL-1, a master regulator of inflammation. Methods We created a genetic score combining the effects of alleles of two common variants (rs6743376 and rs1542176) that are located upstream of IL1RN, the gene encoding t
The information value of non-genetic inheritance in plants and animals.
Parents influence the development of their offspring in many ways beyond the transmission of DNA. This includes transfer of epigenetic states, nutrients, antibodies and hormones, and behavioural interactions after birth. While the evolutionary consequences of such non-genetic inheritance are increasingly well understood, less is known about how inheritance mechanisms evolve. Here, we present a sim
On a problem for Ward's equation with a Mittag-Leffler potential
We solve a problem for a type of non-linear partial differential equation ("Ward's equation"). This is an equation arising naturally in the study of Coulomb gases and random normal matrix ensembles [4]. In this paper, we consider a problem for Ward's equation whose solutions are precisely the well-known Mittag-Leffler functions. Our solution to this problem generalizes certain results obtained in
Construction of Insulin 18-mer Nanoassemblies Driven by Coordination to Iron(II) and Zinc(II) Ions at Distinct Sites.
Controlled self-assembly (SA) of proteins offers the possibility to tune their properties or to create new materials. Herein, we present the synthesis of a modified human insulin (HI) with two distinct metal-ion binding sites, one native, the other abiotic, enabling hierarchical SA through coordination with two different metal ions. Selective attachment of an abiotic 2,2'-bipyridine (bipy) ligand
Følelsernes materiale. Refleksioner over Sonja Åkessons digt "Hvordan ser din farve rød ud"?
Essän undersöker känslornas plats och materialisering i Sonja Åkessons poetiska språk och hur känslokommunikationen i hennes dikt samexisterar en grundläggande misstro mot språkets funktionalitet.
The new ambient-pressure X-ray photoelectron spectroscopy instrument at MAX-lab.
The new instrument for near-ambient-pressure X-ray photoelectron spectroscopy which has been installed at the MAX II ring of the Swedish synchrotron radiation facility MAX IV Laboratory in Lund is presented. The new instrument, which is based on a SPECS PHOIBOS 150 NAP analyser, is the first to feature the use of retractable and exchangeable high-pressure cells. This implies that clean vacuum cond
Characteriazation of the CGRP receptor antagonist telcagepant in human isolated cerebral and meningeal arteries
Optimal control allocation in vehicle dynamics control for rollover mitigation
Vehicle dynamics control systems, previously only intended for yaw stabilization, are now being extended to incorporate rollover mitigation via braking. Current systems typically use a heuristic approach to control allocation, often utilizing only a subset of the available actuators. In this article a computationally-efficient, optimization-based control allocation strategy is used to map controll
Molecular Mechanisms in Amyloid Disorders. Novel Treatment Options in Hereditary Cystatin C Amyloid Angiopathy.
Popular Abstract in Swedish Ett felaktigt protein som klumpar ihop sig i hjärnans blodkärl är orsaken till hjärnblödning och för tidig död hos unga islänningar. Sjukdomen är ärftlig och uppkommer på grund av en enda felaktig byggsten, orsakad av en mutation, i proteinet cystatin C. Det muterade proteinet bildar mikroskopiska proteinkedjor, fibriller, som klumpar ihop sig i bland annat hjärnans bloThe pathophysiological process in Alzheimer’s disease and other amyloid disorders usually involves the transformation of a soluble monomeric protein via potentially toxic oligomers into amyloid fibrils. The structure and properties of the intermediary oligomers have been difficult to study due to their instability and dynamic equilibrium with smaller and larger species. This has hampered the devel
Importance of lipopolysaccharide aggregate disruption for the anti-endotoxic effects of heparin cofactor II peptides
Lipid membrane and lipopolysaccharide (LPS) interactions were investigated for a series of amphiphilic and cationic peptides derived from human heparin cofactor II (HCII), using dual polarization interferometry, ellipsometry, circular dichroism (CD), cryoTEM, and z-potential measurements. Antimicrobial effects of these peptides were compared to their ability to disorder bacterial lipid membranes,