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The discovery that paracetamol is metabolized to the potent TRPV1 activator N-(4-hydroxyphenyl)-5Z, 8Z, 11Z, 14Z-eicosatetraenamide (AM404) and that this metabolite contributes to paracetamol's antinociceptive effect in rodents via activation of TRPV1 in the central nervous system (CNS) has provided a potential strategy for developing novel analgesics. Here we validated this strategy by examining

BACKGROUND: Sexual conflict theory predicts sexually antagonistic coevolution of reproductive traits driven by conflicting evolutionary interests of two reproducing individuals. Most studies of the evolutionary consequences of sexual conflicts have, however, to date collectively investigated only a few species. In this study we used the annual herb Collinsia heterophylla to experimentally test the

In order to deliver innovative and cost-effective IP multimedia applications over mobile devices, there is a need to develop a unified service platform for the future mobile Internet referred as the Next Generation (NG) all-IP network. It is convincingly demonstrated by numerous recent studies that modern multimedia network traffic exhibits long-range dependence (LRD) and self-similarity. These ch

Protein C inhibitor (PCI) is a 57-kDa glycoprotein that exists in many tissues and secretions in human. As a member of the serpin superfamily of proteins it displays unusually broad protease specificity. PCI is implicated in the regulation of a wide range of processes, including blood coagulation, fertilization, prevention of tumors and pathogen defence. It has been reported that PCI isolated from

Purpose - The purpose of this paper is to develop an approach for investigating the impact of surveillance technologies used to facilitate security and its effect upon privacy. Design/methodology/approach - The authors develop a methodology by drawing on an isomorphy of concepts from the discipline of Macroeconomics. This proposal is achieved by considering security and privacy as economic goods,

Activation of thrombin is a critical determinant in many physiological and pathological processes including haemostasis and inflammation. Under physiological conditions many of these functions are involved in wound healing or eradication of an invading pathogen. However, when activated systemically, thrombin can contribute to severe and life-threatening conditions by causing complications such as

BACKGROUND: The production of bio-ethanol from softwood is considered a promising alternative to fossil fuels in Sweden. In order to make fuel ethanol economically competitive with fossil fuels, it is important to reduce the production cost, which can be done by increasing the dry matter content of the fermentation medium, thus reducing the energy demand in the final distillation of the fermentati

Several studies have indicated that mating disruption (MD) successfully reduces population densities of stored product moths, for example, the Mediterranean flour moth, Ephestia kuehniella (Zeller) (Lepidoptera: Pyralidae). However, practical issues, such as finding control plots, replication, and lack of similarity between replicates, often incur problems in full-scale investigations and often dr

Synthesis gas generated by the gasification of nitrogen-containing hydrocarbons will contain ammonia. This is a catalyst poison and elevated levels of nitrogen oxides (NOX) will be produced if the synthesis gas is combusted. This paper presents a study of the selective oxidation of ammonia in reducing environments. The concept is the same as in traditional selective catalytic reduction, where NOX

Electrical machines with distributed concentrated windings are challenging the selection of the soft magnetic materials due to stator design and power conversion efficiency. A shorter magnetisation path and relatively high magnetisation frequency establish a good potential for low permeability soft magnetic materials with low power losses in the core. The focus of this article is on the analysis o

Objective. Secondary hyperparathyroidism (SHPT) is a common problem among patients with chronic kidney disease (CKD) on haemodialysis. This study was conducted to assess the use, effectiveness and safety of intravenous paricalcitol in haemodialysis patients with various degrees of SHPT. Material and methods. This observational, multicentre, prospective study was conducted in 14 Swedish dialysis ce

During the latest early Campanian, a diverse vertebrate assemblage inhabited the shallow coastal waters of the Kristianstad Basin, southernmost Sweden. The taxon-rich fauna includes numerous species of sharks, rays, chimaeroids, bony fish, mosasaurs, plesiosaurs, aquatic birds, crocodiles, and turtles. Vertebrate fossils have been found at several localities within the basin, representing at least

The Qreiya section (Upper Egypt) contains a well-preserved record of the first radiation of the fasciculiths, an evolutionary event that affected the coccolithophores of the Order Discoasterales during the late Danian. At Qreiya it unfolds across the so-called Neo-Duwi Event. We describe the morphostructural changes that affected coccoliths and document a trend towards increased surface area of th

The potential microbial risk from using treated wastewater is a burning issue to be studied. In Sweden, only a small part of treated wastewater is reused directly, although water reuse could be beneficial. Disinfection is virtually never practised and no protective guidelines for water reuse are found in Sweden. Based on a 1 year monitoring programme of water quality, this paper estimates the micr

Abstract in Danish Anmeldelse i ’Fund og Forskning i det Kongelige Biblioteks Samlinger’, Bind 52, 2013, s. 462-66: Kristian Jensen: Revolution and the Antiquarian Book. Reshaping the Past, 1780-1815. Oxford University Press, 2011.