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Characterisation of human AV-nodal properties using a network model

Characterisation of the AV-node is an important step in determining the optimal form of treatment for supraventricular tachycardias. To integrate and analyse patient-specific measurements, mathematical modelling has emerged as a valuable tool. Here we present a model of the human AV-node, consisting of a series of interacting nodes, each with separate dynamics in refractory time and conduction del

Clinical use and limitations of non-invasive electrophysiological tests in patients with atrial fibrillation

Atrial fibrillation (AF) is a complex arrhythmia, that has been studied non-invasively assessing atrial refractory period, atrioventricular node (AV) node refractory period, and ventricular response. The AV node plays a fundamental role as it filters many of the numerous irregular atrial impulses bombarding the node. Despite its importance, the electrophysiological (EP) characteristics of the AV n

Characterization of AV-nodal properties during atrial fibrillation using a multilevel modelling approach

Atrial fibrillation (AF) is a common and increasingly prevalent condition in the western society. During AF, the AV-node controls ventricular response to the rapid atrial impulses. However, current research indicates that the individual variability in AV-nodal function is large. Thus, characterization of the AV-node is an important step in determining the optimal form of treatment on an individual

Noninvasive techniques for prevention of intradialytic hypotension

Episodes of hypotension during hemodialysis treatment constitutes an important clinical problem which has received considerable attention in recent years. Despite the fact that numerous approaches to reducing the frequency of intradialytic hypotension (IDH) have been proposed and evaluated, the problem has not yet found a definitive solution--an observation which, in particular, applies to episode

Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division

Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g. the Par complexes for apical-basal polarity and the Frizzled/Dishevelled complex for PCP), a diverse array of polarized cells and tissues are generated.

Drug effect evaluation during permanent atrial fibrillation using an AV-node model

The purpose of the present study is to evaluate the effect of rate control drugs on the AV node characteristics during atrial fibrillation (AF) using a model-based approach. A statistical model of the AV nodal function is employed, defined by parameters which characterize the arrival rate of atrial impulses, the refractoriness of the fast and the slow AV-nodal pathway and the probability of atrial

Atrial Impulses at the Atrioventricular Node: Arrival versus Conduction during Atrial Fibrillation

The atrioventricular (AV) node plays a central role during atrial fibrillation (AF).We have recently proposed a statistical AV node model defined by parameters characterizing the arrival rate of atrial impulses, the probability of an impulse choosing the slower of the two AV nodal pathways, the refractory periods of the pathways, and the prolongation of refractory periods. All model parameters are

Statistical modeling of atrioventricular nodal function during atrial fibrillation : An update

This paper introduces a number of advancements of our recently proposed model of atrioventricular (AV) node function during atrial fibrillation (AF). The model is defined by parameters characterizing the arrival rate of atrial impulses, the probability of an impulse choosing either one of the two AV nodal pathways, the refractory periods of these pathways, and their prolongation. In the updated mo

Architecture Design of a Memory Subsystem for Massive MIMO Baseband Processing

This brief presents an on-chip memory subsystem for massive multiple-input-multiple-output (MIMO) baseband processing at the base station. In massive MIMO systems, the required memory bandwidth and capacity are orders of magnitude higher than those used in conventional wireless systems, due to the large number of serving antennas. These are further combined with design targets on low access latenc

Paris and Stockholm in the novels Illusions Perdues de Balzac and The Red Room by August Strindberg

ACLA 2017, Seminar with Richard Hibbitt: ”Other Capitals of the Nineteenth Century”Annika Mörte Alling, Lund UniversityParis and Stockholm in the novels Illusions Perdues de Balzac and The Red Room by August StrindbergI propose to study the conceptions of Paris and Stockholm in the two realist novels Illusions Perdues by Honoré de Balzac (1837-1843) and The Red Room (1879) by August Strindberg, pe

Äldre kyrklig konst på Historiska museet i Lund : en katalog

Samlingen av medeltida kyrklig konst från Skåne på Historiska museet i Lund är unik sett till både kvantitet och kvalitet. Här finns nära en tredjedel av landskapets kyrkor representerade och träskulpturen omspänner allt från verk av lokala konstnärer till firade mästare från kontinenten. På museets tredje våning kan besökaren se det mesta och det bästa i en närmast tidlös installation, designad a

Medieval church art at the Historical Museum in Lund : a catalogue

The collection of medieval Scanian church art at the Historical museum of Lund is unique as to both quantity and quality. Here, nearly a third of the churches in the province are represented and the wood sculpture encompasses everything from works by local artists to celebrated masters from the continent. On the second floor of the museum the visitor can see most and the best of it in a nearly tim

The Historical Museum and archaeological research at Lund University 1805-2005

"This account of the Historical Museum and Archaeological Research at Lund University 1805-2005 consists of two parts; a reprint of the history of the Museum including the Archaeological Department until 1984, published that year, and a part comprimising the development during the subsequent twenty years. It describes and discusses the changges and, if possible, the causes of change.The author, Be

What's normal? Immune profiling of human milk from healthy women living in different geographical and socioeconomic settings

Human milk provides a very wide range of nutrients and bioactive components, including immune factors, human milk oligosaccharides, and a commensal microbiota. These factors are essential for interconnected processes including immunity programming and the development of a normal infant gastrointestinal microbiome. Newborn immune protection mostly relies on maternal immune factors provided through

Serum microRNAs in male subfertility—biomarkers and a potential pathogenetic link to metabolic syndrome

Purpose: The purpose of the study was to identify serum microRNAs providing a link between male subfertility and metabolic syndrome (MetS) and validate their diagnostic potential. Methods: Sera were analyzed for fertility and MetS-related parameters in subfertile men (n = 79) and controls (n = 38). Literature review identified miR-155-5p, miR-122-5p, miR-200a-3p, and miR-200c-3p which previously w