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Dynamics in Random Boolean Networks

There are many examples of complex networks in science. It can be genetic regulation in living cells, computers on the Internet, or social and economic networks. In this context, Boolean networks provide simplistic models that are relatively easy to handle using computer simulations and mathematical methods. A good understanding of Boolean networks may form a foundation to investigations of more c

Exploring small heat shock protein chaperones by crosslinking mass spectrometry

Together with other molecular chaperones, small heat shock proteins are key components of the protein quality control system, which is comprised of several hundred proteins and acts to maintain proteome homeostasis in the cell. Small heat shock proteins bind unfolding proteins at an early stage, to prevent these from further unfolding and aggregating. Partially unfolded proteins are being held in

Signalling between plants and microorganisms

Plants and microbes can interact in several ways. Plants can be attacked by different types of pathogens like fungi, virus and bacteria, but can also form symbioses with fungi and bacteria. Certain common antimicrobial proteins are produced by the plants regardless of the type of microbial interaction with the plant. In this work, different factors involved in plant-microbe interactions have been

Apoptosis And Excitotoxicity In The Death of Cultured And Grafted Dopaminergic Neurones

Over the past two decades, grafting of embryonic nigral tissue has developed into a feasible therapeutic strategy for Parkinson's disease (PD). It has become apparent that the degree of restoration of dopaminergic neurotransmission by the transplanted cells is highly correlated to the symptomatic relief. However, the efficacy of the treatment is still far from optimal: More than 90% of the grafted

Nanoscale Crystal Growth: The Importance of Interfaces and Phase Boundaries Kristallväxt på Nanometer Skala: Vikten av Ytor och Gränser

Surfaces and interfaces have a special significance to nanotechnology because the surface/volume ratio of nanomaterials is larger than for bulk materials. Therefore, interfaces of nanomaterials are usually more important to the properties of nanomaterials than for larger scale materials. Furthermore, crystal growth occurs at the interfaces between the growing crystals and the supply media. An unde

Application of the SASW-technique in geotechnical in-situ testing

With the main aim to test the applicability of the surface wave seismic technique Spectral Analysis of Surface Waves (SASW), used for determination of the shear stiffness (shear modulus - Gmax), four areas of applications have been studied. The four areas have been sites with natural geological conditions, sites where non destructive testing is necessary, pavement testing and multichannel testing.

Economic Analyses of Drinking Water and Sanitation in Developing Countries

This thesis focuses on different aspects of household demand, and the determinants of demand, for water and sanitation related inputs fundamental to the households' well-being, i.e. drinking water and toilet facilities. The thesis consists of five chapters, one introductory chapter and four self-contained, essentially empirical, studies. In chapter two, Women's Health Choices and the Effects on C

Quantitative assessment of myocardial infarction: On the relationship between anatomy and electrophysiology using MRI and ECG

Both presence and extent of myocardial infarction are important prognostic factors for mortality and quality of life in patients with ischemic heart disease. Thus, it is of great clinical importance to be able to diagnose and characterize myocardial infarction. One way to diagnose myocardial infarction is by using the 12-lead electrocardiogram(ECG). For estimation of infarct size and location from

Social Insurance, Organization and Hospital Care

This thesis consists of four chapters where chapter 1 introduces the topics in the following chapters and discusses some related literature. Chapter 2 moves beyond the disability insurance with two types, able and disabled, in Parsons (1996). This is done in two ways: by introducing a third type, the partially disabled, and by allowing for a continuum of types. It is assumed throughout that the in

Between Communication and Community : EU Constitution Making, a European Public Sphere and the (Un-)Likelihood of Transnational Debate

What kind of public sphere is possible in the European Union? Against the backdrop of debates on the transformation of democracy beyond the nation-state, this study explores daily newspapers’ role in providing forums for transnational debate in the presumed absence of an overarching European collective identity. It uses empirical means to reconsider the question of the supposed co-constitutiveness

Electrical Studies of Quantum Devices

This thesis deals with electrical measurements on quantum devices. The thesis is divided into three major areas: electrical characterization, semiconductor devices, and metal devices. The electrical characterization part present problems and advantages with the measurement techniques used in the the thesis, .i.e., Current-Voltage; Conductance, including higher order harmonics; Capacitance; Cross-

The Gastrin-ECL Cell Axis. Functional Aspects

The ECL cells constitute a prominent endocrine cell population in the acid-producing part of the stomach. They are controlled by circulating gastrin released from G-cells in the antrum. In response to gastrin, they secrete histamine, that in turn stimulates the parietal cell to secrete acid. The first aim of the study was to prepare isolated ECL cells of high purity and to study and identify regul

Foam Formation and Starch Gelatinization with Alpha-Crystalline Emulsifiers

In the baking industry, emulsifiers in the alpha-gel state are used for foam formation. This thesis focuses on some parts of the effects of the emulsifier: how the foam formation and foam stability are influenced by the physical state of the emulsifier, how emulsifiers change the gelatinization and gel formation of starch, and the impact that these factors may have in a true product such as a spon

Physiology of Caldicellulosiruptor saccharolyticus: a hydrogen cell factory

A high substrate conversion efficiency is a prerequisite for an economically feasible biohydrogen production. Caldicellulosiruptor saccharolyticus is a strictly anaerobic extreme thermophilic bacterium that is able to convert the theoretical maximum of 4 mol/mol glucose to H2. It can grow and produce H2 on a broad spectrum of sugars ranging from monomers (hexoses and pentoses) to more complex suga

Development of Methods for Determination of Fat and Trace Constituents in Food, with Emphasis on Supercritical Fluid Extraction

Sample preparation is the most time-consuming step in an analysis. Traditional sample preparation techniques consume large amounts of organic solvents, are time-consuming and are difficult to automate. During the last decade some new extraction techniques have been developed for sample preparation and one of them is supercritical fluid extraction (SFE). This thesis focuses on sample preparation fo

The Late etruscan votive heads from Tessennano. A study of production, distribution and sociohistorical context.

The Late etruscan terracotta votive heads from Tessennano were found near a rural sanctuary about a hundred km to the North of Rome in 1956. Whereas the facial fronts are serially produced with moulds, the backs are handmade. By using not only the moulded and the handmade features but the raw material (clay and temper) as well, it has been possible to make suggestions as to how, when and where the

A Methodology to Control the Microstructure of Plasma Sprayed Coatings

The aim of this thesis is to enhance the overall understanding of the plasma spray process and increase control and reproducibility of the coating properties. This was performed by establishment of relationships between controllable process parameters, in-flight properties of the injected particles (velocity and temperature), and microstructure properties. The relationships were used to establish

Nucleic Acids as Drug Targets - Influence of Platinum Complexes on Duplex Stability and Binding Kinetics

Gaining a detailed understanding of how human cells are affected by metal-based drugs is crucial, since these drugs have shown great potential in cancer treatment. Cisplatin is used to treat many different types of cancer, e.g. testicular, ovarian, melanoma, bladder, non-small cell lung cancer, small cell lung cancer, myelomas and lymphomas. The miRNA expression profiles in different human cancers

Contrast-Enhanced Magnetic Resonance Angiography - Development and optimization of techniques for paramagnetic and hyperpolarized contrast media

Contrast-enhanced magnetic resonance angiography (CE-MRA) is a diagnostic method for imaging of vascular structures based on nuclear magnetic resonance. Vascular enhancement is achieved by injection of a contrast medium (CM). Studies were performed using two different types of CM: conventional paramagnetic CM, and a new type of CM based on hyperpolarized (HP) nuclei. The effects of varying CM con

Upplysningens självreflexion : Aspekter av Theodor W. Adornos kritiska teori

This dissertation consists of a collection of previously published or otherwise presented essays dealing with the philosophical, sociological and aesthetic writings of Theodor W. Adorno (1903-1969). The title of the dissertation is intended to cover a common programmatic theme running through Adorno's writings. Chapter one, ?Adorno and the Frankfurt school?, deals with the biography of Adorno and