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The Warburg effect is ubiquitous in proliferative mammalian cells, including cancer cells, but poses challenges for biopharmaceutical production, as lactate accumulation inhibits cell growth and protein production. Previous efforts to eliminate lactate production via knockout have failed in mammalian bioprocessing since lactate dehydrogenase has proven essential. However, here we eliminated the Wa

Combination therapies in metastatic hormone-sensitive prostate cancer (mHSPC), which include the addition of an androgen receptor signaling inhibitor and/or docetaxel to androgen deprivation therapy, have been a game changer in the management of this disease stage. However, these therapies come with their fair share of toxicities and side effects. The goal of this observational study is to report

The number of individuals suffering from neuropsychiatric disorders (NPDs) has increased worldwide, with 3 million disability-adjusted life-years calculated in 2019. Though research using various approaches including genetics, imaging, clinical and animal models has advanced our knowledge regarding NPDs, we still lack basic knowledge regarding the underlying pathophysiological mechanisms. Moreover

Background: Climate change can directly affect human health by varying exposure to non-optimal outdoor temperature. However, evidence on this direct impact at a global scale is limited, mainly due to issues in modelling and projecting complex and highly heterogeneous epidemiological relationships across different populations and climates. Methods: We collected observed daily time series of mean te

Introduction: Ampullary neuroendocrine neoplasia (NEN) is rare and evidence regarding their management is scarce. This study aimed to describe clinicopathological features, management, and prognosis of ampullary NEN according to their endoscopic or surgical management. Methods: From a multi-institutional international database, patients treated with either endoscopic papillectomy (EP), transduoden

Mycorrhizal fungi are mutualists that play crucial roles in nutrient acquisition in terrestrial ecosystems. Mycorrhizal symbioses arose repeatedly across multiple lineages of Mucoromycotina, Ascomycota, and Basidiomycota. Considerable variation exists in the capacity of mycorrhizal fungi to acquire carbon from soil organic matter. Here, we present a combined analysis of 135 fungal genomes from 73

BACKGROUND: Among infants with isolated cleft palate, whether primary surgery at 6 months of age is more beneficial than surgery at 12 months of age with respect to speech outcomes, hearing outcomes, dentofacial development, and safety is unknown. METHODS: We randomly assigned infants with nonsyndromic isolated cleft palate, in a 1:1 ratio, to undergo standardized primary surgery at 6 months of ag

Precision nutrition is an emerging concept that aims to develop nutrition recommendations tailored to different people's circumstances and biological characteristics. Responses to dietary change and the resulting health outcomes from consuming different diets may vary significantly between people based on interactions between their genetic backgrounds, physiology, microbiome, underlying health sta

Objective: To compare women's perspectives on the quality of maternal and newborn care (QMNC) around the time of childbirth across Nomenclature of Territorial Units for Statistics 2 (NUTS-II) regions in Portugal during the COVID-19 pandemic. Methods: Women participating in the cross-sectional IMAgiNE EURO study who gave birth in Portugal from March 1, 2020, to October 28, 2021, completed a structu

Objective: To assess the quality of maternal and newborn care (QMNC) in countries of the former Yugoslavia. Method: Women giving birth in a facility in Slovenia, Croatia, Serbia, and Bosnia-Herzegovina between March 1, 2020 and July 1, 2021 answered an online questionnaire including 40 WHO standards-based quality measures. Results: A total of 4817 women were included in the analysis. Significant d

Background: Conservative management is an option for prostate cancer (PCa) patients either with the objective of delaying or even avoiding curative therapy, or to wait until palliative treatment is needed. PIONEER, funded by the European Commission Innovative Medicines Initiative, aims at improving PCa care across Europe through the application of big data analytics. Objective: To describe the cli

Background: Survivors of Hodgkin lymphoma (HL) are at risk of developing non-Hodgkin lymphoma (NHL) after treatment; however, the risks of developing subsequent primary lymphomas (SPLs), including HL and NHL, after different types of childhood cancer are unknown. The authors quantified the risk of SPLs using the largest cohort of childhood cancer survivors worldwide. Methods: The Pan-European Netw

Quantitative reconstructions of past land cover are necessary to determine the processes involved in climate-human-land-cover interactions. We present the first temporally continuous and most spatially extensive pollen-based land-cover reconstruction for Europe over the Holocene (last 11g€¯700g€¯calg€¯yrg€¯BP). We describe how vegetation cover has been quantified from pollen records at a 11 spatia

To verify the fundamental Gerasimov-Drell-Hearn (GDH) sum rule for the first time experimentally, we measured the helicity dependent total photoabsorption cross section with circularly polarized real photons and longitudinally polarized nucleons in the photon energy range 0.68-1.82 GeV with the tagged photon facility at ELSA. The experiment was carried out with a 4pi detection system, a circularly

LUM Lunds universitets magasin | Nr 7 | 2011 idénäste Snille och smak – LU-forskare skriver kokbok Extra arvode skyndade på sakkunniga 2 LUM nr 7 | 2011 rUM för innovation LUM nr 7 | 2011 3 Du behövs! Men du måste häva dig ur det hemtamt trygga, vara beredd att samarbeta med människor olika dig själv. Och inse att kartor inte finns. Inte om du vill upptäcka nå- got nytt eller ”bara” rädda världen.

https://www.lu.se/sites/www.lu.se/files/lunds-universitets-magasin-7-2011.pdf - 2026-05-24

Microsoft Word - On Measuring the Environmental Performance of the Service Sector.doc On Measuring the Environmental Performance of the Service Sector A Case Study of A Service Sector Organisation in Cambridge, UK. A thesis presented in partial fulfilment of the requirements of the Lund University Master’s Programme in Environmental Science, Lund University, Sweden - 22nd November, 2004. Abstract:

https://www.lumes.lu.se/sites/lumes.lu.se/files/blackmore_alistair.pdf - 2026-05-24

Microsoft Word - final version thesis.docx     Human  Development  legitimizing  new   institutions  for  sustainability:   The  problem  of  legitimacy  in  Earth  System  Governance     Tobias  Abrahamsson   tobbe.abbe@gmail.com   August  15th,  2011       Supervised  by:  Turaj  Faran   turaj.faran@lucsus.lu.se   A  thesis  submitted  in  partial  fulfillment  of  the  requirements  of  Lund  U

https://www.lumes.lu.se/sites/lumes.lu.se/files/abrahamsson_tobias_thesis.pdf - 2026-05-24

Flaa,Paul-Hofoss,Dag-Holmer-Hoven,Finn-Medhus,Thorstein-Ronning,Rolf From ‘grey to green’- investigating the capabilities of the bureaucratic system to be an actor in reaching a Sustainable Society: A case study of Region Skåne, Sweden. By: Annie Andersson 1 ABSTRACT Sustainable development policies have for the last 10 years been a part of the Swedish domestic politics. The creation of a green we

https://www.lumes.lu.se/sites/lumes.lu.se/files/annie_andersson.pdf - 2026-05-24

SIMM16 FINAL2 210416 1 GRADUATE SCHOOL METHODS COURSES SIMM16 Introduction to Quantitative Methods Version 1.0 – Oktober 2020 SPRING 2021 2 1. WELCOME SIMM16 INTRODUCTION TO QUANTITATIVE METHODS Contact info Graduate School e-mail: master@sam.lu.se Home page: graduateschool.sam.lu.se Facebook: tinyurl.com/LUgradschoolFB Student Union Home page: samvetet.org Lund University Home page: http://lundun

https://www.graduateschool.sam.lu.se/sites/graduateschool.sam.lu.se/files/2021-04/SIMM16%20FINAL2%20210416.pdf - 2026-05-24

SIMM32 FINAL 210416 1 GRADUATE SCHOOL METHODS COURSES SIMM32 Quantitative Methods: Multivariate Analysis Version 1.0 – Spring 2021 SPRING 2021 2 1. WELCOME SIMM32 QUANTITATIVE METHODS: MULTIVARIATE ANALYSIS Contact info Graduate School e-mail: master@sam.lu.se Home page: graduateschool.sam.lu.se Facebook: tinyurl.com/LUgradschoolFB Student Union Home page: samvetet.org Lund University Home page: h

https://www.graduateschool.sam.lu.se/sites/graduateschool.sam.lu.se/files/2021-04/SIMM32%20FINAL%20210416.pdf - 2026-05-24