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Objective: To evaluate the additive value of the prostate cancer gene 3 (PCA3) urine test to serum prostate-specific antigen (PSA) in prostate cancer (PC) screening among breast cancer, early-onset gene (BRCA) mutation carriers. This study was performed among the Dutch participants of IMPACT, a large international study on the effectiveness of PSA screening among BRCA mutation carriers. Materials

Metamorphic provinces such as the ∼1 ​Ga Grenvillian, ∼400 ​Ma Caledonide and Triassic Qinling Provinces often contain rocks with high-pressure assemblages such as eclogites, which formed at mantle depths in subduction zones. These are evidence of the accretion of terranes by subduction of oceans and collision to form large tectonostratigraphic provinces. The Mesoproterozoic Namaqua-Natal Province

Can Your Genes and Lifestyle Together Shape Your Risk of Parkinson’s Disease? Parkinson’s disease (PD) is one of the most common neurodegenerative disorders worldwide, yet its causes remain only partly understood. While some people inherit rare genetic mutations that directly cause PD, for most individuals, the risk is likely influenced by a complex mix of many common genetic variants and environ

Att bära ett kristet kors runt halsen, en muslimsk huvudduk eller judisk kippa på huvudet är exempel på religiösa manifestationer som arbetsgivaren kan förbjuda genom att införa en neutralitetspolicy, och detta har varit återkommande anledning till debatt i Sverige under de senaste åren. Frågan om neutralitetspolicyer, och arbetsgivarpolicyer i stort, har satt svenska arbetsgivare i en svår situatTo wear a Christian cross around the neck, an Islamic headscarf or a Jewish kippah on the head are examples of religious manifestations which an employer may prohibit through a neutrality policy, and this has been a recurring cause for debate in Sweden in recent years. The question of neutrality policies, and employer policies in general, has put Swedish employers in a difficult situation due to t

Uppsatsen behandlar entreprenörens rätt till tidsförlängning och ersättning vid hinder enligt AB 04 kap. 4 § 3 p. 1 och därtill relevanta bestämmelser i AB 04. Uppsatsen syftar till att öka förståelsen för entreprenörens möjligheter att erhålla tidsförlängning och ersättning för hinder enligt AB 04 kap. 4 § 3 p. 1 och AB 04 kap. 5 § 4. Fokus ligger särskilt på, hur beställarens ansvarskrets bestämThis thesis examines the contractor’s entitlement to extension of time and compensation for delay due to impediments under AB 04, Chapter 4, Section 3, Paragraph 1, and other relevant provisions of AB 04. The purpose of the thesis is to better the understanding of the contractor’s right to obtain time extensions and compensation for delay under AB 04 Chapter 4 Section 3 Paragraph 1 and AB 04 Chapt

White dwarf stars represent the last evolutionary stage of most stars in the Universe. As many of half of these stars are known to have metals in their atmospheres, that must have entered the atmosphere recently. Some also have observable debris discs, hinting that remnant exoplanets provide an important puzzle piece. However, we do not know the full extent of their role, as it is very hard to obs

Syftet med uppsatsen är att utreda när en praktikant är att betrakta som arbetstagare vid tillämpning av kollektivavtal, nationell arbetsrättslig lag samt EU-lagstiftning, samt att utreda hur förslagen till praktikantdirektiv vid ett anta-gande skulle kunna inverka på bedömningen av om en praktikant är arbetsta-gare. I uppsatsen har rättsdogmatisk metod använts. Arbetsdomstolen har vid flera tillThe aim of the thesis is to determine when a trainee is to be regarded as a worker for the purposes of collective agreements and Swedish national labour law, and as a worker under EU legislation, as well as to examine how the proposed directives on traineeships, if adopted, could affect the assessment of whether a trainee is an employee. The thesis uses a legal-dogmatic method. The Swedish Labour

While the situation of queer and trans people within religious communities has gained an increased amount of attention in recent years, with the issue of “conversion therapy” being brought into public discourse by the UN and various LGBTQIA+ organisations, the amount of research that offers in-depth explorations of the living conditions of religious queer and trans people is limited, especially in

Bioenergy plays a major role in the renewable energy supply and is projected to be an important part of the path towards a decarbonised society. Over the past decade, increasing attention has been given to agricultural bioenergy to act as a multifunctional climate mitigation strategy. Energy crops may mitigate climate change while simultaneously contributing to reducing the negative environmental

This is an undeniable fact now that wireless systems pervade all aspects of our lives. These systems are evolving at a rapid clip, connecting more people and devices every single day that goes by. This growth is further fueled by the users’ insatiable appetite for more traffic, be it for online gaming, watching high-fidelity video, downloading huge files, live- streaming and many more uses. With t

Introduction: Anti–glomerular basement membrane (GBM) disease is caused by pathogenic antibodies usually targeting the noncollagenous domain of the α3 chain of type IV collagen and frequently presents as rapidly progressive glomerulonephritis and diffuse alveolar hemorrhage (DAH). Rapid reduction of these antibodies is imperative for kidney survival and the mainstay of therapy is the combination o

This thesis concerns the experimental study of mixing and flow characteristic in turbulent circular impinging jets without and with jet orifice manipulators (i.e. passive-fixed perturbations atthe nozzle exit), without and with swirl. The goal of the studies is to understand the basic mechanisms that control the mixing processes in turbulent impinging jets. The applications of such mixing processe

AbstractCystic fibrosis (CF) is caused by mutations in the anion channel and protein regulator CFTR. The most common co-morbidity in CF is CF-related diabetes (CFRD) affecting ~50% of adult patients. The etiopathology of CFRD is largely unknown but the destruction of the exocrine pancreas is thought to contribute. However, the hypothesis that CFTR has a direct role in the endocrine pancreas has no

Popular Abstract in Swedish Syn är avgörande för många djurs överlevnad. En väldigt viktig del av ögat är linsen då ljuset fokuseras genom den. I denna studie har jag undersökt hur fisklinser fokuserar ljus. Valet av fiskar som försöksdjur berodde på att de är lätta att skaffa och deras linser är klotformade, vilket underlättar beräkningen av strålgången och linsens optiska egenskaper. Hos fiskar Vision is an important source of information for many animals. The lens plays a central role in the visual pathway and hence the ecology of these animals. Fish have spherically shaped crystalline lenses that contain a gradient of refractive index. Like all refracting elements, lens performance depends on the wavelength of the refracted light. This wavelength dependent focusing leads to chromatic a

Group exhibition. Participated with the work Light to the Nations .Will the sky fall on our heads one day? Meteorites have a magical attraction, but at the same time they fuel age-old fears. Whereas in the Middle Ages they were regarded as divine signs and ominous devil’s stones, today people fear a natural disaster: a meteorite impact that could wipe out our civilisation. Perhaps not such a far-f

Background: Preterm infants are susceptible to hyperglycaemia and hypoglycaemia, which may lead to adverse neurodevelopment. The use of continuous glucose monitoring (CGM) devices might help in keeping glucose levels in the normal range, and reduce the need for blood sampling. However, the use of CGM might be associated with harms in the preterm infant. Objectives: To assess the benefits and harms

High resolution observations with ALMA have revealed that concentric rings and gaps are common features in protoplanetary disks. The favored mechanism for creating these substructures are planet-disk interactions, in which growing planets open gaps in the disk, and particles become trapped at the pressure maxima that form at the corresponding gap edges. Since the particle density in these pressure