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OBJECTIVES: The aim of this study was to compare fully quantitative cardiovascular magnetic resonance (CMR) and positron emission tomography (PET) myocardial perfusion and myocardial perfusion reserve (MPR) measurements in patients with coronary artery disease (CAD).BACKGROUND: Absolute quantification of myocardial perfusion and MPR with PET have proven diagnostic and prognostic roles in patients

Diffusion tensor imaging (DTI) has been used to study microstructural white matter alterations in a variety of conditions including normal aging and Alzheimer’s disease (AD). White matter hyperintensities (WMH) are common in cognitively healthy elderly as well as in AD and exhibit elevated mean diffusivity (MD) and reduced fractional anisotropy (FA). However, the effect of WMH on statistical analy

BACKGROUND: The tumor microenvironment plays an important role in the progression of cancer by mediating stromal-epithelial paracrine signaling, which can aberrantly modulate cellular proliferation and tumorigenesis. Exposure to environmental toxicants, such as inorganic arsenic (iAs), has also been implicated in the progression of prostate cancer.OBJECTIVE: The role of iAs exposure in stromal sig

AIMS/HYPOTHESIS: Genetic and environmental factors are believed to cause type 1 diabetes. The aim of this study was to investigate the influence of maternal BMI and gestational weight gain on the subsequent risk of childhood type 1 diabetes.METHODS: Children in the Swedish National Quality Register for Diabetes in Children were matched with control children from the Swedish Medical Birth Register.

BACKGROUND: Medical decision making has long been in focus, but little is known of the preferences and conditions for elderly people with co-morbidities to participate in medical decision making. The main objective of the present study was to investigate the preferred and the actual degree of control, i.e. the role elderly people with co-morbidities wish to assume and actually had with regard to i

Background: Caldicellulosiruptor saccharolyticus is an attractive hydrogen producer suitable for growth on various lignocellulosic substrates. The aim of this study was to quantify uptake of pentose and hexose monosaccharides in anindustrial substrate and to present a kinetic growth model of C. saccharolyticus that includes sugar uptake on defined and industrial media. The model is based on Monod

With advancing age, changes in the arterial wall contribute to what has been called vascular aging, and in some prematurely affected subjects even early vascular aging (EVA).1–5 Several years ago,1 we listed various components of EVA, including arteriosclerosis, atherosclerosis, and excess vasoconstriction, with their clinical expression: arterial stiffening and increased central pulse pressure, c

Botulinum neurotoxins (BoNTs) are a family of bacterial toxins with seven major serotypes (BoNT/A-G). The ability of these toxins to target and bind to motor nerve terminals is a key factor determining their potency and efficacy. Among these toxins, BoNT/B is one of the two types approved for medical and cosmetic uses. Besides binding to well-established receptors, an extended loop in the C-termin

Mikrober finns överallt, runt omkring oss i vår miljö och inuti våra kroppar. De som lever tillsammans med djur har mycket stor påverkan på värdens hälsa och evolutionära fitness. Från ett djurs perspektiv är vissa mikrober goda, andra onda, och vissa har ingen större påverkan på hälsan, men egentligen beror dessa egenskaper på sammanhanget, eftersom det är vanligt att mikrober byter strategi tillThe microbes living inside hosts have highly important consequences for host health and fitness. From the host’s perspective, some microbes exhibit mutualistic tendencies, others parasitic, and some commensal, but this is context-dependent and opportunistic lifestyles are widespread in nature. Our knowledge of how hosts interact molecularly with different microbes is, however, poor, and little res

Context. Determination and calibration of the ages of stars, which heavily rely on stellar evolutionary models, are very challenging, while representing a crucial aspect in many astrophysical areas. Aims. We describe the methodologies that, taking advantage of Gaia-DR1 and the Gaia-ESO Survey data, enable the comparison of observed open star cluster sequences with stellar evolutionary models. The

Preeclampsia (PE) is an important pregnancy complication that affects 3-8% of women worldwide and is a leading cause of maternal and fetal morbidity and mortality. It is known that PE is associated with placental dysfunction, resulting in hypoxia, oxidative stress, altered metabolism and production of inflammatory cytokines. Hypoxia could enhance erythropoiesis and induce non-erythroid hemoglobin

Multimetal smithing should be defined as the use of more than one metal and/or different metalworking techniques within thesame crafts-milieu. This complex metalworking has long been linked to centrality, central places and urbanity in Scandinavia.It has been extensively argued that fine casting and smithing, as well as manufacture utilizing precious metals was exclusivelyundertaken within early u