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Highly dimensional single cell analysis of peripheral inflammation in ALS with mass cytometry

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with neither a known cause nor an available cure. With disease progression, toxic protein aggregates form in the brain, leading to the loss of the upper and lower motor neurons. While circulating bone marrow-derived inflammatory cells have not been shown to cross the blood brain barrier, changes in their number and comp

Examining German road supply chain triads with subcontractors - A sender’s perspective

Purpose – The road freight industry is becoming more and more complex. An increasing number of actors participating in the transport process has been highlighted. Simultaneously, transport constellations become more fragmented. With transport as feature of the product-offer, sending companies face new challenges. While transport has as part of the product offer influence on the customer satisfacti

Trade unions' freedom of association in Cambodia - A study on the Trade Union Law and its possible implications on trade unions in the Cambodian garment industry

Syftet med denna uppsats är att analysera Fackföreningslagen och dess potentiella konsekvenser för fackföreningars föreningsfrihet i den kambodjanska textilindustrin. Utöver detta analyseras lagen i förhållande till redan befintlig nationell lagstiftning samt i relation till internationell rätt rörande föreningsfrihet. Majoriteten av Fackföreningslagens regleringar är oförenliga med internationeThe aim of the thesis is to elaborately analyse the Trade Union Law and its possible implications for trade unions’ right to freedom of association in the Cambodian garment industry. In addition, the law is evaluated in relation to already existing domestic law and in relation to international law regarding freedom of association. The majority of the Trade Union Law’s provisions are incompatible

Stakeholders' Opinions on a Future In-Vehicle Alcohol Detection System for Prevention of Drunk Driving

Introduction: There is a common understanding that driving under the influence of alcohol is associated with higher risk of being involved in crashes with injuries and possible fatalities as the outcome. Various countermeasures have therefore from time to time been taken by the authorities to prevent drunk driving. One of them has been the alcohol interlock. Up to now, interlocks have mainly been

Perceptions of disease. Values and attitudes of patients and medical students

Popular Abstract in Swedish Sjukdomsuppfattningar. Värderingar och attityder hos patienter och medicine studerande. Utvecklingen av den biomedicinska kunskapen och de demografiska förändringarna under 1900-talet har inneburit en ökning av såväl behov av som efterfrågan på hälso- och sjukvård. Illabefinnande utan påvisbara sjukdomstecken och rädsla för sjukdom ligger ofta bakom vårdsökande. OfficieDuring the 20th century, the development of biomedical knowledge and the demographical changes have increased the needs and demands for health care in industrialised countries. Illness without evidence of disease and fear of disease are often the reasons for seeking medical care. Primary care is the official foundation of the Swedish health care system but priorities are vague and frequently chang

Developing internal crisis communication: New practices for communication professionals

Purpose - The article has two major purposes. The first purpose is to examine the roles and practices of communication professionals in relation to internal aspects of crisis communication. The second purpose is to suggest new roles and practices for communication professionals that will enable a strategic approach to internal crisis communication. This article is based on empirical material from

Gene Expression Profile of Colon Cancer Cell Lines Treated with SN-38

Aim: Colorectal cancer is the third most common form of cancer in the industrial countries. Due to advances regarding the treatments, primarily development of improved surgical methods and the ability to make the earlier diagnosis, the mortality has remained constant during the past decades even though the incidence in fact has increased. To improve chemotherapy and enable personalised treatment,

Life cycle assessment in green chemistry: overview of key parameters and methodological concerns

Several articles within the area of green chemistry often promote new techniques or products as 'green' or 'more environmentally benign' than their conventional counterpart although these articles often do not quantitatively assess the environmental performance. In order to do this, life cycle assessment (LCA) is a valuable methodology. However, on the planning stage, a full-scale LCA is considere

Underlying causes and level of learning from accidents reported to the MARS database

MARS is the system established and maintained by the European Commission in order to collect information related to major industrial accidents in EU Member States in the context of the Seveso II Directive. One of the main purposes of the MARS database is to provide information for learning from the accidents to avoid similar events. Probably, the most important issue for the learning is the determ

Current practice, challenges and potential methodological improvements in environmental evaluations of food waste prevention - A discussion paper

A review was performed of eight previously performed investigations of environmental impacts from end-consumer food waste prevention. The overall aim of the study was to investigate the state of the art in these assessments, identify key factors which could explain seen variations in GWP-emission savings, and suggest methodological improvements leading to increased potentials for cross-study compa

An Inquiry into Cultural Semiotics: Germaine de Staël's Autobiographical Travel Accounts

Popular Abstract in Swedish Kultursemiotiken studerar möten mellan kulturer. Begreppen Kultur, Extra-kultur och Icke-kultur utvecklades av Tartuskolan under 1970-talet, och användes i deras studier av den ryska kulturen och dess relation till Västeuropa. Särskild vikt lades vid Peter den Stores försök att göra Ryssland mer likt Väst. Målet med denna avhandling i kultursemiotik är att vidareutvecklCultural semiotics studies encounters between cultures. Notions such as Culture, Extra-culture and Non-culture were developed in the 1970s by the Tartu school and were used in their studies of Russian culture and its relation to Western Europe, with special focus on Peter the Great's attempt to Westernize Russia in the eighteenth century. The aim of this dissertation in cultural semiotics is to fu

Mapping of quick clay using geoelectrical imaging and CPTU-resistivity

Quick clay has a major impact on landslide risk and it is therefore of considerable interest to map its presence and extent. In Sweden, quick clay has been involved in most landslides in soft clay with serious consequences. The predominant method for detection of quick clay in Sweden has been to take undisturbed samples and to perform fall-cone tests on the clay in its undisturbed and remoulded st

Bioinspired Hydrogenase Models: The Mixed-Valence Triiron Complex [Fe3(CO)7(μ-edt)2] and Phosphine Derivatives [Fe3(CO)7-x (PPh3) x (μ-edt)2] (x = 1, 2) and [Fe3(CO)5(κ(2)-diphosphine)(μ-edt)2] as Proton Reduction Catalysts.

The mixed-valence triiron complexes [Fe3(CO)7-x (PPh3) x (μ-edt)2] (x = 0-2; edt = SCH2CH2S) and [Fe3(CO)5(κ(2)-diphosphine)(μ-edt)2] (diphosphine = dppv, dppe, dppb, dppn) have been prepared and structurally characterized. All adopt an anti arrangement of the dithiolate bridges, and PPh3 substitution occurs at the apical positions of the outer iron atoms, while the diphosphine complexes exist onl

Ärftlighetsforskningens gränser : Individer och institutioner i framväxten av svensk genetik

Popular Abstract in Swedish Den moderna genetiken tar sin början kring sekelskiftet 1900 då de mendelska lagarna återupptäcktes. Den tidiga utvecklingen skedde i många länder i nära anslutning till den praktiska växtförädlingen, så även i Sverige där det redan fanns en framgångsrik växtförädling genom Sveriges utsädesförenings verksamhet i Svalöf. Här introducerade botanisten Herman Nilsson-Ehle mIn the first part of the 20th century genetics developed into an important research field. The aim of this study is to follow and analyse the transformation of genetics from its origin within an agricultural context to an academic discipline in Sweden (ca. 1900-1960). Mendelism was introduced as a methodology in plant breeding at the plant breeding station in Svalöf during the first decade of the

Long-term population dynamics and in situ physiology in activated sludge systems with enhanced biological phosphorus removal operated with and without nitrogen removal

Quantitative fluorescence in situ hybridization (FISH) and the combination of FISH with microautoradiography (MAR) were used in order to study the long-term population dynamics (2.5 years) and the in situ physiology in two parallel activated sludge pilot systems with enhanced biological phosphorus removal (EBPR). The two systems received the same influent wastewater, but were differently operated

Rättighet och Rättvisa : Användbarhet av rättighet och rättvisa i sociala projekt

Popular Abstract in Swedish I de hänvisningar som används i ett stort antal sociala projekt för att målet skall uppnås hittas rättighet och rättvisa som centrala diskursiva enheter i en återkommande använd tankemodell. I flera av dessa projekt blir resultatet, gång efter annan, utebliven framgång. Men den samma rätta tankemodellen förblir en självklar utgångspunkt. De upprepade krigen mot fattigdoIn the references invoked by a large number of social projects to achieve their goals, one can find rights and justice as central discursive units in a frequently recurring thought model. In several of these projects the result, time after time, is lack of success. But the same right thought model continues to be taken for granted as a point of departure. The repeated wars on poverty in the USA ex

Selection of Resistant Streptococcus pneumoniae during Penicillin Treatment In Vitro and in Three Animal Models.

Pharmacokinetic (PK) and pharmacodynamic (PD) properties for the selection of resistant pneumococci were studied by using three strains of the same serotype (6B) for mixed-culture infection in time-kill experiments in vitro and in three different animal models, the mouse peritonitis, the mouse thigh, and the rabbit tissue cage models. Treatment regimens with penicillin were designed to give a wide

Probabilistic Analysis and Reliability of Engineering Structures

This thesis, consisting of six papers, concerns methods for probabilistic analysis of engineering structures. The work comprises evaluations of available methods, developments of new and improved methods, and applications of probabilistic analysis to engineering structures. Comparative calculations using methods representing different strategies for stochastic finite element analysis were carried

Trisomies in Hematologic Malignancies

Acquired clonal chromosome aberrations, closely associated with leukemogenesis, are found in many hematologic malignancies. Although the balanced rearrangements, such as translocations and inversions, are the ones most commonly thought of in the context of leukemias, gains of chromosomes ? e.g.., trisomies ? are also frequent. Little is known about the biologic outcome, the pathogenetic significan

Norms and legal rules : An investigation of the tunnel construction through the Hallandsås ridge

Popular Abstract in Swedish Tunnelbygget genom Hallandsåsen har utvecklats på ett sådant sätt och fått sådana konsekvenser, att frågan hur projektet skall förstås och förklaras är viktig. Vill man studera vilka mekanismer i samhället som kan förhindra projektets förlopp eller dess konsekvenser, bör man först förstå projektet. Matthias Baiers bok handlar om hur man med normer kan förstå och beskrivIn 1992 Swedens biggest tunnelproject begun. Two 8.5 km tunnels should cross a big ridge in southern Sweden which was seen as an obstacle to a fast and efficient railway line connecting Oslo and Gothenburg with Malmö and Copenhagen. However, the project had to stop in 1997 due to environmental damages. With only a third of the tunnel accomplished, the project was also much delayed and had a heavy