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Purpose: To identify strategies that can be applied to achieve a sustainable position when the equilibrium state has changed. Problem: Research question 1: What factors should be analyzed to predict how disruptive innovations change market structures? Research question 2: What strategies can an innovator apply to achieve a sustainable position at a new equilibrium? Research question 3: How are the

Ultraljud och mikrochip kan hjälpa oss att förstå cancer bättre En tumör och dess omgivning spelar stor roll i hur cancer utvecklas och genom att förstå vilka celler den består av och sortera ut de viktigaste kan man öka kunskapen om hur cancern bäst ska bekämpas. I detta arbete har immunceller från sådan upplöst bröstvävnad sorteras ut med hjälp av ett mikrochip med små kanaler samt en ultraljudThe aim of this thesis was to compare different ways of dissociating tissue - specifically breast cancer tissue - and sorting out tumour cells and immune cells from the dissociated tissue using acoustophoresis in a microfluidic chip. Due to ethical issues with using tumour tissues to work on the methodology of a project, ultimately only healthy breast tissue was used in this work. Two dissociatio

Databehandling av signaler från millimetervågsradar i realtid Radarsensorer som använder millimetervågor är väldigt användbara inom avkänningsteknik, som har tillämpningar inom bland annat sjukvården, autonoma robotar, osv. Detta examensarbete bygger vidare på en genomförbarhetsstudie som med positiva resultat undersökte om det var möjligt att med hjälp av elektronik och algoritmer förhindra fallBased on the feasibility study [4], the goal of this master thesis is to compile custom firmware for the XM112 Pulsed Coherent Radar Module, which features a state of the art radar sensor integrated with a microcontroller unit (MCU). This allows the use of custom firmware to check the plausibility of real-time data processing on the radar signals and will lay some of the groundwork for further dev

Radar - Dina ögon i nacken när du cyklar Cyklister är en utsatt grupp av trafikanter för olyckor. För att öka säkerheten kan radarteknologi användas för övervakning av döda vinkeln samt ge mervärde till fordonet. Med en enkel notis så kommer man undvika risken med att inte veta vad som kommer bakifrån.The purpose of this thesis is to develop a blind spot detection system for increased safety and comfort for a biker. The solution is based on power-efficient small A111 radars, developed by Acconeer AB, which have a range up to seven meters while consuming only a few milliwatts. Sensor evaluation is performed for the intended use and from this, concepts are generated. These are tested to obtain t

Prediction of flood and evaluation of the impact of climate change in a catchment needs to be correctly estimated, which can be accomplished by hydrological modelling in HEC-HMS. In this paper, the objectives were to gain an understanding of the rainfall-runoff process and estimate the flood frequency curve in the Kävlinge River Basin. However, due to the complexity of a catchment, models should b

Macaneta spit is located about 30km north of Maputo, Mozambique, with the Indian Ocean on the east side and Incomáti River on the west side of the spit, composing an interesting and vulnerable area from a hydrodynamic point of view. Few studies regarding coastal processes are done in the area and changes of the morphology could result in breaching of the spit and thereby affect both accessibility

In two previous studies, optimal conditions were identified for two-step steam pretreatment Of SO2- and H2SO4-impregnated softwood. In the present study the yield of sugar and ethanol was determined in a process development unit where pretreatment was performed in a 10-L reactor and simultaneous sacchatification and fermentation (SSF) or enzymatic hydrolysis (EH) were performed in 30-L reactors. T

Background: Within Europe many guidelines exist regarding the genetic testing of minors. Predictive and presymptomatic genetic testing of minors is recommended for disorders for which medical intervention/preventive measures exist, and for which early detection improves future medical health. Aim: This study, which is part of the larger 5th EU-framework "genetic education'' (GenEd) study, aimed to

Measurement of cortisol concentration can contribute important information about an individual's ability to adjust to various environmental demands of both physical and psychosocial origin. However, one uncertainty that affects the possibilities of correctly interpreting and designing field studies is the lack of observations of the impact of seasonal changes on cortisol excretion. For this reason

Traditional gold mining, using metallic mercury (Hg-0) to form gold amalgam, followed by burning to remove the Hg-0, is widely used in South America, Africa and Asia. The gold is sold to merchants who burn it again to eliminate remaining Hg-0. In Ecuador, 200 gold miners, 37 gold merchants and 72 referents were studied. The median Hg concentrations in urine (U-Hg) were 3.3 (range 0.23-170), 37 (3.

OBJECTIVES: Increased vulnerability to stress has been suggested as a possible mechanism behind medically unexplained conditions such as sensitivity to electricity and common smells. This study examined whether subjective environmental annoyance among the general population is associated with increased physiological reactivity or subjective stress scores.METHODS: Four groups were studied (N=141):

Background: The size of pancreatic ductal adenocarcinoma (PDAC) at diagnosis is an indicator of outcome. Previous studies have focused mostly on patients with resectable disease. The aim of this study was to investigate the relationship between tumour size and risk of metastasis and death in a large PDAC cohort, including all stages. Methods: Patients diagnosed with PDAC between 1988 and 2013 were

BACKGROUND: Although people with intellectual disability (ID) and people with dementia have high drug prescription rates, there is a lack of studies investigating drug use among those with concurrent diagnoses of ID and dementia.AIM: To investigate the use of antipsychotics, benzodiazepine derivatives, and drugs recommended for dementia treatment (anticholinesterases [AChEIs] and memantine) among

Background: Central nervous system (CNS) involvement is associated with relapse in childhood acute lymphoblastic leukemia (ALL) and is a diagnostic challenge. Procedure: In a Nordic/Baltic prospective study, we assessed centralized flow cytometry (FCM) of locally fixed cerebrospinal fluid (CSF) samples versus local conventional cytospin-based cytology (CC) for detecting leukemic cells and evaluati

Investigation of contaminant sources is indispensable for developing effective countermeasures against nitrate (NO3 −) pollution in groundwater. Known major nitrogen (N) sources are chemical fertilizers, livestock waste, and domestic wastewater. In general, scatter diagrams of δ18O and δ15N from NO3 − can be used to identify these pollution sources. However, this method can be difficult to use for

The impact of different drying techniques and storage conditions on the formation of carboxymethyl lysine (CML) as an advanced glycation end product (AGE) was investigated in various pilot-scale produced skim milk powders (SMP). CML, an indicator of advanced stages of the Maillard reaction, was analyzed by isotope dilution ESI-LC-MS/MS after drying and at intervals during storage for 200 days. The

OBJECTIVE: To investigate the impact of exercise therapy on molecular biomarkers related to cartilage and inflammation in people at risk of, or with established, knee osteoarthritis by conducting a systematic review of randomized controlled trials (RCTs).METHODS: Literature search up to September 2017 in five major databases with no restriction on publication year or language. Data were extracted

High or low ambient temperatures pose a risk factor for the worsening or onset of psychiatric disorders. The aim of this study was to investigate the association between ambient temperature and psychiatric emergency visits in an urban region in a temperate climate. The daily number of visits to a psychiatric emergency room (PEVs) at Sahlgrenska University Hospital, Gothenburg, Sweden and the daily

A group of 38 male workers at a secondary smelter (period of employment 2-35 years; median 10 years) was divided into two subgroups depending on bone-lead concentration, arranged as 19 matched pairs according to age, education and job level. The median concentrations for finger-bone lead (Bone-Pb) were 16 vs. 32 μg/g; for current blood-lead (B-Pb), 1.6 vs. 1.8 μmol/l; for retrospective peak blood-

Mine waste rock piles (WRPs) can contain sulfidic minerals whose interaction with oxygen and water can generate acid mine drainage (AMD). Thus, WRPs can be a long-term source of environmental pollution. Since the generation of AMD and its release into the environment is dependent on the net volume and bulk composition of waste rock, effective characterization of WRPs is necessary for successful re