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Antibody-based microarrays are a rapidly emerging technology that has advanced from the first proof-of-concept studies to demanding serum protein profiling applications during recent years, displaying great promise within disease proteomics. Miniaturized micro- and nanoarrays can be fabricated with an almost infinite number of antibodies carrying the desired specificities. While consuming only min
The suppressors of cytokine signaling ( SOCS) family is thought to act largely as a negative regulator of signaling by cytokines and some growth factors. Surprisingly, the SOCS-6 transgenics had no significant defects in the cytokine signaling and hematopoietic system but displayed significant improvements in glucose metabolism. Insulin stimulation of Akt/protein kinase B was also potentiated. Bio
Twice each year, millions of night-migratory songbirds migrate thousands of kilometers. To find their way, they must process and integrate spatiotemporal information from a variety of cues including the Earth's magnetic field and the night-time starry sky. By using sensory-driven gene expression, we discovered that night-migratory songbirds possess a tight cluster of brain regions highly active on
Hematopoietic stem cell (HSC) numbers are tightly regulated and maintained in postnatal hematopoiesis. Extensive studies have supported a role of the cytokine tyrosine kinase receptor Kit in sustaining cycling HSCs when competing with wild-type HSCs posttransplantation, but not in maintenance of quiescent HSCs in steady state adult bone marrow. In this study, we investigated HSC regulation in Whit
This paper presents a pilot study on the prosodic marking of a contrastive topic in Southern Swedish. A test sentence was elicited in three experimental conditions: initial focus; final focus; contrastive topic (initial word) plus focus (final word). F0 patterns were analysed in recordings of 10 speakers. A majority of the speakers distinguished clearly between the conditions, but speakers employe
This paper considers off-line optimization of a switching sequence fora given finite set of linear control systems and joint optimization ofcontrol laws. A linear quadratic full information criterion isoptimized and dynamic programming is used to find the optimalswitching sequence and control laws. The main result is a method for efficient pruning of the search tree to avoid combinatoric explosion
To optimize productivity and working-life quality, it is important to understand and utilise the connections between productivity and working environment. Culture and the state of the market may affect the strength of these connections. However, in order to ensure flexibility and quality in products and services, it may be useful to have motivated, skilled and responsible coworkers at all levels.
Biodiversity offsets are most commonly used to mitigate the adverse impacts of development on biodiversity, but some offsets are now also designed to support ecosystem services (ES) goals. Here, we assemble a global database of biodiversity offsets (n = 70) to show that 41% already take ES into consideration, with the objective of enhancing cultural, regulating, and provisioning services. We found
BACKGROUND: Basal cell carcinoma (BCC) is the most common skin cancer. Incidence is largely unknown because of incomplete, or lack of, registration in most countries.OBJECTIVES: To assess current incidence rates and recent trends for BCC in the Swedish population.METHODS: Patient- and tumour-related features of all histologically confirmed BCC tumours diagnosed in Sweden from 2004 to 2017 were ext
Supermassive black holes (SMBHs) are found in most galactic nuclei. A significant fraction of these nuclei also contains a nuclear stellar cluster (NSC) surrounding the SMBH. In this paper, we consider the idea that the NSC forms first, from the merger of several stellar clusters that may contain intermediate-mass black holes (IMBHs). These IMBHs can subsequently grow in the NSC and form an SMBH.
OBJECTIVE - The efficacy and Safety of adding liraglutide (a glucagon-like peptide-1 receptor agonist) to Metformin were compared with addition of placebo or glimepiride to metformin in subjects previously treated With oral antidiabetes (OAD) therapy. RESEARCH DESIGN AND METHODS - In this 26-week, double-blind, double-dummy, placebo- and active-controlled, parallel-group trial, 1,091 subjects were
Screening mammography plays a key role in the early detection of breast cancer, however, estimates of sensitivities (48-88%) and specificities (82-98%) suggest that the diagnostic accuracy can be improved (1, 2, 3). Breast tomosynthesis (BT) is a 3D technique that is expected to improve breast cancer detection compared to screen-film and digital mammography DM). This work presents two clinical obs
Sammanfattning Det är enbart arbetstagare som omfattas av det arbetsrättsliga skyddet i lagstiftningen. Därmed utgör arbetstagarbegreppet en viktig del av arbetsrätten. Definitionen av begreppet får en allt större betydelse då sättet att organisera arbetet förändras kontinuerligt i och med att nya anställningsformer tillkommer. Uppsatsen undersöker hur EU och Sverige definierar och tillämpar arbAbstract The Labour law protection only covers those who are considered employees. Thus, the concept of employee is a significant part of the Labour law. The definition is becoming increasingly important as the way of organizing the work is continuously changing as new forms of employment are added. The essay examines how the EU and Sweden define and apply the concept of employee and what similar
Denna utredning granskar hur proportionalitetsprincipen används i ett förarbete som föreslår straffskärpningar. Syftet är att problematisera huruvida proportionalitetsprincipen kan tillförsäkra enhetliga bedömningar av förhållandet mellan brott och straff på ett sätt som tillgodoser intresset av rättvisa bestraffningar och en begränsning av statens bestraffande makt. Utredningen granskar därför prThis thesis examines how the principle of proportionality is used in a law proposal that suggests increased penalties. It aims to problematize if the principle of proportionality can ensure stable assessments of the relationship between crime and punishment in a way that satisfies the interest of fair punishment and that limits the punitive power of the state. It is therefore interested in examini
Solens påverkan på klimatet är ett hett ämne i dagens klimatdebatt och utgör en av de största osäkerheterna i vår kunskap om klimatsystemet. Det finns flera sätt som förändringar i solaktivitet skulle kunna påverka klimatet på. En av de föreslagna länkarna mellan solaktivitet och klimat är att den galaktiska kosmiska strålningen (GCR) påverkar bildningen av låga moln. På grund av att låga moln harThe solar influence on climate is a hot topic in today’s climate debate and constitutes one of the largest uncertainties in our knowledge about the climate system. There are several ways in which solar activity changes could affect climate. One of the suggested links between solar activity and climate is an influence from galactic cosmic rays (GCR) on the formation of low clouds. Because of the ne
Syftet med denna studie är att undersöka fyra nutida pianopedagogers syn på hur Frédéric Chopins pianometodik har utvecklats från kompositörens tid fram till nutid. Litteraturen som används för denna studie fokuserar på Chopins tankar om undervisning, Chopin-spel under olika tider, samt traditionsöverföring. Studien baseras på personliga intervjuer och en kvalitativ metod. Data samlas in genom intTitle: "Clever, but not Chopinesque" - A study of four contemporary piano pedagogues’views on Frédéric Chopin’s piano method through the years The purpose of this study is to investigate four contemporary piano pedagogues’ views on how Frédéric Chopin’s pedagogical piano method has developed from the time of the composer to the present day. The literature used for this study focused on C
