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Cause and effect in biology revisited: Is Mayr’s proximate-ultimate dichotomy still useful?

Fifty years ago, Ernst Mayr published a hugely influential paper on the nature of causation in biology, in which he distinguished between proximate and ultimate causes. Mayr equated proximate causation with immediate factors (for example, physiology) and ultimate causation with evolutionary explanations (for example, natural selection). He argued that proximate and ultimate causes addressed differ

Simulation of compact heat exchanger performance

Purpose - The purpose of this paper is to present some methods to analyse and determine the performance of compact heat exchangers; show the applicability of various computational approaches and their limitations, provide examples to demonstrate the methods, and present results to highlight the opportunities and limitations of the considered methods. Design/methodology/approach - Engineering metho

Active feedback regulation of a Michelson interferometer to achieve zero-background absorption measurements

An active phase-controlling scheme based on a proportional-integral-derivative-controlled piezoelectric transducer is presented with the purpose of stabilizing a quasi-zero-background absorption spectrometer. A fiber-based balanced Michelson interferometer is used, and absorption due to a gas sample in one of its arms results in an increased light signal to a detector, which otherwise, thanks to d

Factors affecting health-related quality of life in patients after femoral neck fracture

Quality of life in patients with femoral neck fracture is an issue frequently discussed in the literature. There is ongoing research on identifying factors that have an impact on quality of life in this particular group of patients. A great variety of factors affecting quality of life and lack of information on their importance encouraged us to perform a systematic literature review analyzing qual

Super High Dosing with a Novel Buttiauxella Phytase Continuously Improves Growth Performance, Nutrient Digestibility, and Mineral Status of Weaned Pigs

This study was conducted to evaluate the efficacy of a novel Buttiauxella phytase to pigs fed P-deficient, corn-soybean meal diets. One hundred and twenty crossbred piglets (9.53 +/- 0.84 kg) were allocated to one of five treatments which consisted of four low P diets (0.61 % Ca and 0.46 % total P) supplemented with 0, 500, 1,000, or 20,000 FTU/kg phytase as well as a positive control diet (0.77 %

Smelling your way to food: can bed bugs use our odour?

The resurgence in developed countries of the common bed bug, Cimex lectularius, has led to a search for new sustainable methods to monitor and control this human ectoparasite. Because of increased resistance to insecticides, traps baited with attractive cues are considered a promising method to be developed into efficient monitoring tools for bed bugs. Despite their potential as attractants, only

Measurement of the inclusive jet cross-section in proton-proton collisions at root s=7 TeV using 4.5 fb(-1) of data with the ATLAS detector

The inclusive jet cross-section is measured in proton-proton collisions at a centre-of-mass energy of 7 TeV using a data set corresponding to an integrated luminosity of 4.5 fb(-1) collected with the ATLAS detector at the Large Hadron Collider in 2011. Jets are identified using the anti-k(t) algorithm with radius parameter values of 0.4 and 0.6. The double-differential cross-sections are presented

Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice

The 8p11 myeloproliferative syndrome (EMS), also referred to as stem cell leukemia/lymphoma, is a chronic myeloproliferative disorder that rapidly progresses into acute leukemia. Molecularly, EMS is characterized by fusion of various partner genes to the FGFR1 gene, resulting in constitutive activation of the tyrosine kinases in FGFR1. To date, no previous study has addressed the functional conseq

Ballistic imaging in the near-field of an effervescent spray

We have investigated liquid breakup mechanisms in the near nozzle region of a high-pressure effervescent atomizer using ballistic imaging. This technique has revealed various breakup regimes depending upon total flow rate and the gas-to-liquid ratio (GLR). At low total speeds, the jet does not exhibit the wide spread angle and rapid breakup for which effervescent sprays are known, even at high GLR

Study of the porous structure of white chocolate by confocal Raman microscopy

Confocal Raman microscopy has been shown to be a useful technique for investigation of white chocolate surfaces. The appearance of protrusions and pores, and the distribution of fat, sucrose, and milk powder at and below the surface of white chocolate pralines were investigated using confocal Raman microscopy. Raman horizontal and depth scans showed that the protrusions and pores continue at least

Thoughts and feelings of future working life as a predictor of return to work: a combined qualitative and quantitative study of sick-listed persons with musculoskeletal disorders

Purpose. The main aim of this study was to describe the thoughts and feelings of future working life related to return to work (RTW) in sick-listed persons due to musculoskeletal disorders (MSD). Further aim was to compare these descriptions with the person's actual working situation 1, 5 and 10 years after a rehabilitation period. Methods. This study consisted of two parts. The first part had an

Neutron powder diffraction - new opportunities in hydrogen location in molecular and materials structure

The potential of neutron powder diffraction in the location of hydrogen atoms in molecular materials and inorganic-molecular complexes is reviewed. Advances in instrumentation and data collection techniques that have made this field accessible are reviewed, along with a wide range of applications carried out by our collaboration investigating functional materials, hydrogen-containing minerals and

The structure of allozyme variation in Silene nutans (Caryophyllaceae) in Denmark and in north-western Europe

We used allozymes to investigate the structure of genetic variation in populations of the perennial herb Silene nutans at local (Denmark), regional (Nordic area) and wide (over a 19A degrees latitudinal gradient) geographic scales in north-western Europe. New data from Denmark were combined with data from previously studied Fennoscandian and western populations. We related patterns of nuclear vari

Interactive effects of landscape history and current management on dispersal trait diversity in grassland plant communities

Summary Plant communities and their ecosystem functions are expected to be more resilient to future habitat fragmentation and deterioration if the species comprising the communities have a wide range of dispersal and persistence strategies. However, the extent to which the diversity of dispersal and persistence traits in plant communities is determined by the current and historical characteristic

Giant prolactinomas in women

Objective: To characterise distinctive clinical features of giant prolactinomas in women. Design: A multicentre, retrospective case series and literature review. Methods: We collected data from 15 female patients with a pituitary tumour larger than 4 cm and prolactin levels above 1000 mu g/l and identified 19 similar cases from the literature; a gender-based comparison of the frequency and age dis

Cord blood insulinoma-associated protein 2 autoantibodies are associated with increased risk of type 1 diabetes in the population-based Diabetes Prediction in Skane study

Aims/hypothesis The aim of this study was to examine the effect of cord blood autoantibodies on the risk for type 1 diabetes in children followed prospectively from birth. Methods The Diabetes Prediction in Skane (DiPiS) study consists of 35,853 children from the general population born during 2000-2004. Samples were collected at birth and analysed for HLA genotypes and autoantibodies to glutamate