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Chromosomal aberrations in solid tumors appear in complex patterns. It is important to understand how these patterns develop, the dynamics of the process, the temporal or even causal order between aberrations, and the involved pathways. Here we present network models for chromosomal aberrations and algorithms for training models based on observed data. Our models are generative probabilistic model
Background: Patients with hypertrophic cardiomyopathy (HCM) have a high incidence of atrial fibrillation. They also have a longer P-wave duration than healthy controls, indicating conduction alterations. Previous studies have demonstrated orthogonal P-wave morphology alterations in patients with paroxysmal atrial fibrillation. In the present study, the P-wave morphology of patients with HCM was co
Four adenosine receptor subtypes of the family of G protein-coupled receptors, designated A1, A2A, A2B and A3 are currently known. In this study all human subtypes were stably transfected into Chinese hamster ovary (CHO) cells in order to be able to study their pharmacological profile in an identical cellular background utilizing radioligand binding studies (A1, A2A, A3) or adenylyl cyclase activi
Many cross-border regions in Europe remain more political dreamscapes than examples of strong transnational integration.The development of the Öresund region through a bridge linking Copenhagen and eastern Denmark with Southern Sweden has been seen as a model for EU region building. Drawing on a multidisciplinary project, this article uses the Öresund case as a starting point, bringing in some con
This paper treats four saxicolous species of Caloplaca occurring mainly in subtropical or semiarid regions in North and Central America, C. baueri, C. cinnabarina, C. rosei, and C. rubelliana. These species are mainly characterized by 1) a continuous to cracked areolate thallus, 2) thallus without marginal lobes, 3) areole margins broadly attached to the substrate, 4) cortex distinctly paraplecten
We have used microarray gene expression pro. ling and machine learning to predict the presence of BRAF mutations in a panel of 61 melanoma cell lines. The BRAF gene was found to be mutated in 42 samples (69%) and intragenic mutations of the NRAS gene were detected in seven samples (11%). No cell line carried mutations of both genes. Using support vector machines, we have built a classifier that di
Analysis of high-frequency QRS components (HF-QRS) might provide an additional method when diagnosing various heart diseases, for example ischemic heart disease (HID). This study compares HF-QRS in normal Subjects to those in patients with HID, and also analyzes HF-QRS considering gender and age. A total of 63 normal subjects and 64 patients with IHD were included. Signal-averaged electrocardiogra
Partially ecologic case-control studies combine group-level exposure data with individual-level data on disease status, group membership, and covariates. If the exposure measure is the exposure prevalence of various groups, the attributable fraction (AF; the estimated proportion of cases that are attributable to exposure) can be estimated by classifying all subjects in groups with exposure prevale
New palaeomagnetic data from the autochthonous Early Cambrian Dividal Group (northern Scandinavia) confirm earlier findings, and a refined palaeomagnetic pole of 58.4degreesN and 122.5degreesE, places Baltica at intermediate southerly latitudes at similar to535 Ma. Palaeomagnetic data from the immediately underlying granitic basement (pole: 9.8degreesN, 226.7degreesE) differ markedly from the Divi
Hyperlipidemia appears to play an integral role in loss of glucose-stimulated insulin secretion (GSIS) in type 2 diabetes. This impairment can be simulated in vitro by chronic culture of 832/13 insulinoma cells with high concentrations of free fatty acids, or by study of lipid-laden islets from Zucker diabetic fatty rats. Here we show that impaired GSIS is not a simple result of saturation of lipi
Readers acquire information outside the current eye fixation. Previous research indicates that having only the fixated word available slows reading, but when the next word is visible, reading is almost as fast as when the whole line is seen. Parafoveal-on-foveal effects are interpreted to reflect that the characteristics of a parafoveal word can influence fixation on a current word. Prior studies
In this paper a method for obtaining affine structure from an image sequence taken by a translating camera with constant intrinsic parameters is presented. A general geometric constraint, expressed using the camera matrices, is derived and this constraint is used in a least squares solution of the problem. The first step is to obtain a projective reconstruction, in the form of a sequence of camera
The biosynthesis of selenoproteins was studied in relation to milk formation and mammary cell biology by incubating the bovine mammary cell line MAC-T with (75Se)selenite. Intracellular proteins and proteins secreted into the cell culture medium were separated by 2D electrophoresis, the selenoproteins were detected by autoradiography, and the proteins were identified by MALDI-TOF. Approximately 35
The present study prospectively examined the relationship between cytomegalovirus interstitial pneumonia (CMV-IP) and viral load among 56 renal transplant recipients. We sought to identify the cutoff of viral load to predict CMV-IP. Blood samples were obtained weekly within the first 2 months and every second week during 2 to 6 months after kidney transplantations. A commercial real-time polymeras
