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Triparental Families: A New Genetic-Epidemiological Design Applied to Drug Abuse, Alcohol Use Disorders, and Criminal Behavior in a Swedish National Sample.

Objective: The authors sought to clarify the sources of parent-offspring resemblance for drug abuse, alcohol use disorders, and criminal behavior, using a novel genetic-epidemiological design. Method: Using national registries, the authors identified rates of drug abuse, alcohol use disorders, and criminal behavior in 41,360 Swedish individuals born between 1960 and 1990 and raised in triparental

CD40L is not involved in acute experimental pancreatitis

Recent data suggest that platelets not only control thrombosis and hemostasis but may also regulate inflammatory processes such as acute pancreatitis. However, the specific role of platelet-derived mediators in the pathophysiology of acute pancreatitis is not known. Herein, we examined the role of CD40 ligand (CD40L, CD154) in different models of acute pancreatitis. Acute pancreatitis was induced

Evaluation of the Mechanical Properties of PMMA Reinforced with Carbon Nanotubes - Experiments and Modeling

The effective mechanical properties of polymethyl-methacrylate (PMMA) reinforced with carbon nanotubes (CNTs) were evaluated by means of two approaches: experiments and a micromechanical model. With various concentrations of CNTs, two specimen fabrication processes were examined: hot pressing (HP) and injection molding (IM). Experiments included a series of uniaxial tensile tests guided by an ASTM

Rapid production of cellulase-free xylanases by solventogenic Clostridia from rumen

Xylanases without contaminating cellulases are produced by a wide variety of aerobic bacteria and fungi but anaerobic organisms producing such enzymes are rare. Clostridial species viz., Clostridium beijerinckii LU-1, C. acetobutylicum LU-1, C. butyricum and C. bifermentans LU-1 isolated from rumen produced xylanase (E.C. 3.2.1.8) of 1.5-4.2 U/ml on oat spelt xylan as sole carbon source. Cellulose

Origins and projections of nerve fibres in rat pyloric sphincter.

Nerve fibres play an important role in the regulation of gastric emptying. The aims of this study were to clarify the distribution, projections and origin of neuronal type nitric oxide synthase (NOS)-, tyrosine hydroxylase (TH)-, vesicular acetylcholine transporter (VAchT)- and peptide-containing nerve fibres of the rat pyloric sphincter. Extrinsic and local denervations of the sphincter were perf

Kinetics and equilibria for complex formation between palladium(II) and chloroacetate

Kinetics and equilibria for the formation of a 1:1 complex between palladium(II) and chloroacetate were studied by spectrophotometric measurements in 1.00 mol . dm(-3) HClO4 at 298.2 K. The equilibrium constant, K, of the reaction Pd2+ + HL reversible arrow PdL+ + H+ was determined from multi-wavelength absorbance measurements of equilibrated solutions at variable temperatures as log(10)K (298.2K)

Use of neural networks to improve quality control of interpretations in myocardial perfusion imaging

Background: The aim of this study was to explore the feasibility of using a technique based on artificial neural networks for quality assurance of image reporting. The networks were used to identify potentially suboptimal or erroneous interpretations of myocardial perfusion scintigrams (MPS). Methods: Reversible perfusion defects (ischaemia) in each of five myocardial regions, as interpreted by on

Influence from fuel type on the performance of an air-blown cyclone gasifier

Entrained flow gasification of biomass using the cyclone principle has been proposed in combination with a gas engine as a method for combined heat and power production in small to medium scale (<20 MW). This type of gasifier also has the potential to operate using ash rich fuels since the reactor temperature is lower than the ash melting temperature and the ash can be separated after being collec

Ser129 phosphorylation of endogenous α-synuclein induced by overexpression of polo-like kinases 2 and 3 in nigral dopamine neurons is not detrimental to their survival and function.

Phosphorylation of the α-synuclein (α-syn) protein at Ser129 [P(S129)-α-] was found to be the most abundant form in intracellular inclusions in brains from Parkinson's disease (PD) patients. This finding suggests that P(S129)-α-syn plays a central role in the pathogenesis of PD. However, it is at present unclear whether P(S129)-α-syn is pathogenic driving the neurodegenerative process. Rodent stud

Learning Objects and their implications on Learning: a case of developing the foundation for a new Knowledge Infrastructure

In an era of lifelong learning, empowerment of the learner becomes fundamental. Therefore ex-ploitation of the full potential of learning objects depends upon creation of an appropriate infra-structure to promote symmetrical control of inquiry. The learner needs to be empowered because learning is a discovery process and thus must be under his or her own control. In early stages of education it

Modifying Cooking Practices to Reduce the Formation of Heterocyclic Amines

Popular Abstract in Swedish Vid tillagning av kött, och framför allt stekning och grillning, bildas mutagena ämnen i stekskorpan. Dessa ämnen benämns heterocykliska aminer. Flera epidemiologiska studier har visat ett samband mellan uppkomsten av cancer och intaget av heterocykliska aminer, medan några studier inte finner något samband. Ämnena har också visat kunna utveckla tumörer och cancer i djuCommonly cooked meat dishes contain heterocyclic amines (HAs) at ng/g levels. HAs are animal carcinogens, form DNA adducts in human tissues, and have been associated with increased risk of cancer in epidemiological studies, and it is thus recommended that human intake be decreased. The aim of this investigation was to find ways of modifying cooking practices to reduce the formation of HAs. Various

Incentives to catalyse green building certifications for building construction

In the construction industry, sustainability and greening is more than just a passing trend. It has become an important agenda since the building sector has immense environmental impacts. It accounts for 42% of final energy consumption and about 35% of all greenhouse gas emissions. In order to meet these challenges, the construction industry needs to change and adopt new working procedures which t

HCCI Operation - Closed loop combustion control using VVA or dual fuel

Popular Abstract in Swedish Den nuvarande teknologin inom förbränningsmotorer har möjligheten att hantera den alltmer strikta myndighetskraven på förbränningsmotorn. Emellertid de nödvändiga tekniska lösningarna som krävs är dyra och alltmer tekniskt krävande. En möjlig väg mot enklare efterbehandlingssystem är anvädningen av Homogen Kompressions Antändning (Eng: HCCI) motor cykeln. Den huvudsaklThe current technology within combustion engines have the possibility of handling the more stringent legislative demands on combustion engines. However the required solutions are getting more expensive and technically challenging. One possible way towards a more simple exhaust aftertreatment system is the use of the Homogeneous Charge Compression Ignition (HCCI) engine cycle. The main advantage o

Thermodynamic Simulation of HCCI Engine Systems

Popular Abstract in Swedish Avhandlingen omfattar förutom en kort inledning, i huvudsak två delar: (1) Beskrivning av teorin bakom ett datorbaserat verktyg för simulering av termodynamiken i ett motorsystem, där främst motorer med Homogen Kompressionsantändning (Homogeneous Charge Compression Ignition, HCCI) avses. Med system avses förutom själva motorn, turboladdare, laddluftkylare, insug och avgThis thesis focuses on engine system simulation using thermodynamics and chemical kinetic models to investigate the performance and efficiency of Homogeneous Charge Compression Ignition (HCCI) engines for stationary applications. It includes the development of software as well as models for engine, turbocharger, intercooler, inlet and exhaust manifolds, wastegate valve, inlet air humidifier, inle

Pedagogy of Heuristic Contexturalisation: Intercultural transmission through cross-cultural encounters

Popular Abstract in Swedish Denna doktorsavhandling i ämnet pedagogik utgör en analys av effekter av den pågående kulturella globaliseringen genom att granska två internationella magisterprogram vid Lunds universitet. Studiens syfte är att spåra mönster i en bärande pedagogisk idé för överföring av ett interkulturellt tänkande i tvärkulturella möten genom att utforska, beskriva och försöka förstå The present study is designed to analyze the effects of the ongoing cultural globalization. It utilizes as its empirical setting two special programmes called the International Master's Programme (the IMP,) directed by Lund University in Sweden. The aim of the study is to infer a pedagogic idea for intercultural transmission through cross-cultural encounters by exploring, describing, and comprehen

Lead abundance in the uranium star CS 31082-001

In a previous paper we were able to measure the abundance of uranium andthorium in the very-metal poor halo giant BPS CS31082-001, but only obtained an upper limit for the abundanceof lead (Pb). We have got from ESO 17 h of additional exposure on thisstar in order to secure a detection of the minimum amount of leadexpected to be present in CS 31082-001, the am

Distribution and functional significance of phosphodiesterase isoenzymes in the human lower urinary tract

To date, it is widely accepted that several disorders of the male and female urogenital tract, such as erectile dysfunction, bladder overactivity, urinary stone disease and the benign prostatic syndrome, can be therapeutically approached by influencing the function of the smooth musculature of the respective organs. In order to achieve a pronounced drug effect without significant adverse events, e

Understanding what it means to be a Montessori teacher: Teachers' reflections on their lives and work.

Popular Abstract in Swedish Det övergripande syftet med föreliggande studie är att utveckla en bättre förståelse om vad det innebär att vara montessorilärare. Utgångspunkten är lärarnas egna liv- och verksamhetsberättelser. Insamling av data har skett genom loggböcker, intervjuer, skriftliga reflektioner och diskussioner. Analys av lärarnas livsberättelser i samband med övriga data har granskats fThe overall aim of this study has been to come to a better understanding of what it means to be a Montessori teacher, by getting a group of Montessori teachers to reflect on their lives and work. Data exploration has comprised journals, interviews, written reflections and collaborative contextual analysis. Analysis of the teachers' occupational life histories and the findings as a whole have been

Numerical Simulation of Some Heat Transfer and Fluid Flow Phenomena for Gas Turbine Blades and a Transonic Turbine Stage

With the attempts to achieve higher thermal efficiency, turbine blades are exposed to very high temperature gases and may undergo severe thermal stress and fatigue. Thus, in order to develop optimal cooling strategies and reduce the heat transfer it is important to obtain a good understanding of both the complex flow field and the heat transfer characteristics in turbine rotor/stator hot-gas passa