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Germline mutations are the ultimate source of genetic variation and the raw material for organismal evolution. Despite their significance, the frequency and genomic locations of mutations, as well as potential sex bias, are yet to be widely investigated in most species. To address these gaps, we conducted whole-genome sequencing of 12 great reed warblers (Acrocephalus arundinaceus) in a pedigree s
BACKGROUND: The advent of PD-1/PD-L1 inhibitors has revolutionized lung cancer treatment, necessitating accurate PD-L1 immunohistochemical (IHC) assessment. While standardized for formalin-fixed paraffin-embedded (FFPE) histological samples, PD-L1 testing on cytology remains challenging. This review aims to address the complexities of PD-L1 IHC in cytology, focusing on validation guidelines, quali
Background: Problem gambling and gambling disorder cause severe social, psychiatric, and financial consequences, and voluntary self-exclusion is a common harm reduction tool used by individuals with gambling problems. Objective: The aim of this study was to explore users’ experience of a novel nationwide, multioperator gambling self-exclusion service, “Spelpaus,” in Sweden and to inform stakeholde
This corpus study addresses the question of the nature and the structure of antonymy and synonymy in language use, following automatic methods to identify their behavioral patterns in texts. We examine the conceptual closeness/distance of synonyms and antonyms through the lens of their DOMAIN instantiations.
This paper discusses how archaeologists might investigate issues of poverty by focusing on poorhouses. The poor and deprived are rarely prominent objects in archaeological research, probably because archaeologists find it difficult to relate to a concept such as poverty. At the same time, there is material culture that can be clearly linked to poverty. One such materiality is poorhouses. While the
In this paper we consider the problem of linear quadratic regulator (LQR) performance for cascade control structures of series coupled systems. The necessary and sufficient condition for the linear quadratic performance of a cascade control structure to achieve the same performance as any given centralized LQR is obtained. The cascade problem could be seen as a special case of the network control
Control is traditionally applied using periodic sensing and actuation. In some applications, it is beneficial to use instead event based control, to communicate or make a change only when necessary. There are no known general closed form solutions to such event based control problems. We consider stationary event-based control problems with mixed continuous/discrete time dynamics and stochastic di
Most fundamentals modes of the water dimer have been experimentally determined, and the frequencies have been measured in either neon or parahydrogen matrices. The band strengths of all intramolecular and most intermolecular fundamentals of the water dimer have been measured. The results are further corroborated by comparison with the corresponding data for the fully deuterated water dimer. DFT ca
In the West, everybody is now talking about the economic and financial crisis. The term ‘’crisis” has become a buzzword within both academic and policy communities. There is an enormous upsurge of scholarly interest in the effects of this crisis on public administration systems, and the role that public administration plays in these processes. The underlying belief is that the public administratio
Professional women in the end of the 19ht and the beginning of the 20th century. Emancipation, women's rights, relationes between women and women, and women and men. Sexuality, hetero/homosexuality. Equality of the sexes.
A method for rapidly assessing a patient's arterial stiffness and hence risk of developing cardiovascular disease (CVD) without resorting to laborious blood tests is presented. Simple measurement of a patient's volume pulse measured at the finger-tip (digital volume pulse) using an infrared light absorption detector placed on the index finger is sufficient to predict their CVD risk. Suitable featu
In this chapter it is argued that the feminist pioneer Mary Wollstonecraft regarded moral agency as an exercise of freedom; a person who is unfree cannot perform acts that are moral in the proper sense. There are three aspects to this deprivation: first, the psychological effects of oppression; second, processes of deliberation and reasons for action, and third, the moral character of an act, such
Our purpose in this chapter is to give a brief perspective on islands in global historical-political ecology, focusing on ecologically unequal exchange and the formation of landesque capital. We emphasize how these processes are intertwined and recursively connected in broader contexts of uneven development. Empirical examples draw on our research into the historical-political ecology of islands a
Abstract in UndeterminedThe base of the world income pyramid, generally called the ‘Base of the Pyramid’ (BoP), consists of four billion people with average per day income of less than four dollars. Over the past several years, the design and development of products and services at the BoP (BoP people as producers and consumers as well) has been investigated by several authors from different disci
Meso-tetra(hydroxyphenyl)chlorin (mTHPC) (international generic name Temoporfin) is a potent photosensitizer used for photodynamic therapy (PDT). In this study the pharmacokinetics of a systemically administered novel lipid formulation of Temoporfin in a murine tumor model has been investigated. Fluorescence spectroscopy measurements were performed at several time intervals following drug administ
The Environmental Determinants of Diabetes in the Young (TEDDY) Study aims at examining the associations between islet autoimmunity and various environmental exposures (e.g. diet) in Finland, Germany, Sweden and the United States (US). In order to produce comparable results from dietary assessments, the national food composition databases (FCDB) must contain mutually comparable food composition da
A number of policy instruments are used in order to provide consumers healthy products produced in a proper way as regards environmental impacts. The policy instruments are mainly directed to enterprises and companies producing products. Such actors are often addressed in terms of laws or regulations and represent different actors in a production chain. Policy instruments and the way they are used
I detta konferensbidrag ifrågasätter jag åsikten att litteraturteori inte bör läras ut på gymnasienivå. Enligt den franske litteraturteoretikern Tzvetan Todorov bör läraren på denna nivå endast lära ut litterära verk, inte teori. Teorin borde endast användas som ett osynligt verktyg. Min hypotes är att litteraturteorin kan användas framgångsrikt på gymnasiet. Viss insikt i teorin kan bidra till atIn this paper I challenge the opinion that literary theory should not be taught at upper secondary level. According to French literary theorist Tzvetan Todorov, the teacher at this level should aim at teaching literary works, not theory. Theory should only be used as an invisible instrument. My hypothesis is that literary theory can be used successfully at upper secondary level. A certain insight
