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Russ et al. show that human astrocytes adopt different reactive immune phenotypes when exposed to either TNF-α or alpha-synuclein fibrils, which are exogenous stressors that compete to drive the astrocyte immune reactive response. They also show that PARK2-variant-containing astrocytes exhibit an exacerbated response to the stressors, accompanied by bioenergetic defects.
This study presents how sequential infiltration synthesis of trimethyl aluminium and water into a carbohydrate-based block copolymer was used to enable pattern transfer of 6 nm half-pitch horizontal cylinders into silicon. Specular neutron reflectometry measurements of poly(styrene)-block-maltoheptaose self-assembled into horizontal cylinders indicate an increasing content of alumina after each se
An in vitro model was developed to characterize the electrical properties of silicon microfabricated recording electrodes, using a Cu-wire mimicing a neural signal source. Phosphorous doped electrodes were used to achieve an all silicon device. The model was used to study signal amplitude as a function of distance between the electrode surface and the signal source. Signal crosstalk to neighbourin
Purpose of Review: This review sought to describe quality improvement initiatives in fragility fracture care and prevention. Recent Findings: A major care gap persists throughout the world in the secondary prevention of fragility fractures. Systematic reviews have confirmed that the Fracture Liaison Service (FLS) model of care is associated with significant improvements in rates of bone mineral de
Preliminary mobile was considered to be a device to make human connections easier. But today the consumption of this device has been evolved to a platform for gaming, web surfing and GPS-enabled application capabilities. Embedding GPS in handheld devices, altered them to significant trajectory data gathering facilities. Raw GPS trajectory data is a series of points which contains hidden informatio
The present study aims to describe accelerometer-assessed physical activity (PA) patterns and fulfillment of PA recommendations in a large sample of middle-aged men and women, and to study differences between subgroups of socio-demographic, socio-economic, and lifestyle-related variables. A total of 27 890 (92.5% of total participants, 52% women, aged 50–64 years) middle-aged men and women with at
Rapporten presenterar resultaten av en studie som vi genomfört på uppdrag av Nätverket Idéburen Sektor Skåne och handlar om idéburna erfarenheter av samverkan med offentliga organisationer inom NAD. Syftet är att förstå hur strukturella förändringar och organisatoriska strategier har påverkat samverkan över tid. Tidsperioden sträcker sig från 2016 då vi genomförde en utvärdering av samverkan och 2
This chapter aims to provide practical evidence-based guidance in the use of generative artificial intelligence (GenAI) for the design and management of authentic assessment tasks and provide a grounding for institutional policy conversations so that decisions can be influenced in a constructive learner-centric way. Drawing on the foundational principles of assessment and feedback, we critically e
Aeolian transport rates decreases during wet conditions as the threshold shear velocity for initiation of transport increases over moist sand. This study investigates the influence of surface moisture on meso-scale aeolian transport simulations. Yearly transport rates towards the dunes are simulated with ten different threshold-based models to account for moisture effects. The ten models show larg
Although deep neural networks (DNNs) are high-performance methods for various complex tasks, e.g., environment perception in automated vehicles (AVs), they are vulnerable to adversarial perturbations. Recent works have proven the existence of universal adversarial perturbations (UAPs), which, when added to most images, destroy the output of the respective perception function. Existing attack metho
The aim of the present study was to determine the pollution load originating from storm water on Lake Vaxjosjon. Each year about 1,050,000 m3 of storm water are discharged into the lake. Storm water represents a substantial pollution source for the lake and therefore also a main reason for the hypertrophic conditions in the lake. In order to evaluate the effects of the discharged storm water on th
The use of protective gloves is of importance in workplaces where hazardous chemicals are handled, including the chemical industry, the plastic industry, as well as in environments such as dental practices, hairdressing, and beauty salons. Occupational dermatology can provide crucial advice regarding how to avoid or protect the patient against allergens found in the work environment and provide th
Organizational ambidexterity has emerged as a research area promoting innovation for both short- and long- term success. Structural ambidexterity proposes dual structures and strategies to differentiate efforts, focusing on one or the other form of innovation. In contrast, contextual ambidexterity relies on behavioral and social means to integrate exploitation and exploration. In this article we h
