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Pharmacodynamics of amoxicillin/clavulanic acid against Haemophilus influenzae in an in vitro kinetic model: a comparison of different dosage regimens including a pharmacokinetically enhanced formulation

OBJECTIVE: To study the pharmacodynamics of amoxicillin/clavulanic acid against different strains of Haemophilus influenzae in an in vitro kinetic model. The concentrations used corresponded to human serum levels obtained after 875 mg amoxicillin/clavulanic acid given b.i.d., 500/125 mg amoxicillin/clavulanic acid given t.i.d. and those obtained with a pharmacokinetically enhanced formulation cont

Staten, företagen och arbetskraftsinvandringen - en studie av invandringspolitiken i Sverige och rekryteringen av utländska arbetare 1960-1972

This dissertation investigates the labour migration from Southern Europe to Sweden, and the changes in Swedish immigration policy between 1960 and 1972. The overall ambition is to bring both the state and employers into the analysis of immigration policy and the recruitment of foreign labour - not separately but together in one study. The dissertation is divided into two main parts. The first part

Magnitude and time-course of arterio-venous differences in blood-alcohol concentration in healthy men

Background and objective: Human studies of arterio-venous (AV) differences in drug concentrations and the consequences for pharmacokinetic modelling and concentration-effect relationships are very limited. We therefore investigated the intravenous and intra-arterial concentrations of alcohol (ethanol) during the absorption, distribution and elimination stages of alcohol metabolism in healthy men.

Inflammation-sensitive plasma proteins are associated with future weight gain.

Cross-sectional studies have associated obesity and other components of the so-called metabolic syndrome with low-grade inflammation. The temporal and causal relations of this association have not been fully explored. This study explored whether elevated levels of inflammation-sensitive plasma proteins (ISPs) (fibrinogen, orosomucoid, {alpha}1-antitrypsin, haptoglobin, and ceruloplasmin) are assoc

"Spanska fönstret" - dubbel skattefrihet?

Det är vanligt förekommande att fysiska och juridiska personer vill minska sin beskattning. Det finns stor variation i förfaringssätt som medför minskad beskattning. Denna uppsats undersöker om dubbel skattefrihet kan uppstå vid hemvistbyte. Dubbel skattefrihet innebär att varken den nya eller tidigare hemviststaten beskattar personen. På så sätt blir vissa inkomster skattefria. Det har tidigare fIt is common that physical and legal entities want to reduce their taxation, and there are several processes available. This paper examines whether double exemption of tax can arise when changing residence. Double non-taxation means that neither the new nor previous state of residence will tax that entity. Some income will therefore be excluded from taxation. Such a process has previously been pos

Chemical composition of the Pulp and Seed Kernels of Baobab fruits from three different African Countries

The baobab is among the commonly consumed wild fruits found in the semi-arid regions of sub-Saharan Africa. It has a wide application in food systems and folk medicine and has an advantage of surviving even in harsh environmental conditions. While the fruit pulp is packed with a lot of essential nutrients and has gained much interest in recent past on the international market as a healthy ‘superfo

"Vi bygger en stad": En studie om kulturella föreställningar i stadsplaneringen

I den här kulturanalytiska studien undersöker jag de kulturella normer och värderingar som ligger till grund för hur Stockholms stad bedriver stadsplanering. Mitt fokus är på de personer som gör stadsplaneringen, de så kallade stadsplanerarna. Ambitionen är att genom intervjuer med dem få kunskap om de kulturella föreställningar om trygghet och ordning i stadsplaneringen som ligger till grund för In this cultural analytical study, I am investigating cultural concepts of security and order in the city planning. My analysis is based on Mary Douglas's theory that describes human perception of deviations, dangers and security presented in the book Purity and Danger. In addition, I use Jürgen Habermas' book The Structural Transformation of the Public Sphere, in which he explores how the

För barnets bästa? En kritisk granskning av internationella adoptioners förenlighet med principen om barnets bästa

Vid alla rättsliga förfaranden som rör barn ska principen om barnets bästa beaktas. Principen är väl omdiskuterad och det finns ingen universell fastslagen definition. Internationella adoptioner är en av processerna som ska utgå från principen. Detta stadgas i såväl nationell lagstiftning som internationella konventioner. Rådande diskurs om internationella adoptioner har under de senaste decennierIn every legal process regarding children, the principle of best interests of the child must be considered. The principle is well discussed and does not have a universal determined definition. Intercountry adoption is one of the proceedings that must consider the principle. This is stipulated in both national and international law. During the last decades, the prevailing view on intercountry adopt

Feasibility of adaptive SBRT of prostate cancer: Investigating uncertainties in AI-driven and CBCT-guided online adaptive radiotherapy

Cancer kan drabba vem som helst och kan ha sitt ursprung i många olika områden i kroppen. Antalet nya cancerfall ökar varje år, men vissa typer av cancer har bättre prognos än andra. Den vanligaste cancertypen i Sverige är prostatacancer och den drabbar framför allt äldre män. Prostatacancer har god prognos och det finns effektiva metoder att helt bota prostat- acancer om den behandlas i ett tidigPurpose: Recent developments in external radiotherapy and its utilization with artificial in- telligence (AI) enables advanced treatment plans for a range of different disease sites. By adapting to the anatomy of the day, target coverage can be ensured while sparing more healthy tissue. The purpose of this project was to study the feasibility and benefits of daily cone beam computed tomography (CB

Stepping Down Fatigued or Not: What Makes Flight Crews Decide to Step Down From Duty.

With the emergence of industrialisation, the work-life balance has become a point of discussion in many industries, among which the aviation industry. Distortions in the work-life balance became especially apparent when 24/7 economies evolved, and industries made a transition to facilitate and serve these economies. Incidents and accident have since then been related to fatigue more than before. T

Searching for a link between AID-mediated mutations and patterns of transcription initiation and pausing in activated B cells

Activation-induced cytidine deaminase (AID) is an enzyme and key component of both 15 class-switch recombination and somatic hypermutation, two mechanisms used by activated B 16 cells to diversify their antigen repertoire, as it catalyzes the deamination of deoxycytidines turning 17 them into deoxyuridines, introducing mutations in immunoglobulin genes. AID, however, can also 18 target enhancer re

Egyptology in the Periphery. Valdemar Schmidt and the making of Egyptology in Denmark 1872–1925

Egyptology in the 19th and early 20th centuries developed simultaneously with increased imperial presence in Egypt by the European imperial powers, which would have influence on how the discipline was practised. The history of Egyptology has for this reason primarily focused on the big four – Great Britain, France, Germany and USA – and on Egypt itself. The aim of this study is to examine how Egyp

Idén om den ideella föreningen som juridisk person - en rättsvetenskaplig undersökning kring utformningen av, och kraven för, rättspersonlighet för ideella föreningar i Sverige, Norge och Finland

Ideella föreningar är en fundamental del av det svenska samhället. I hög grad tack vare en vidsträckt föreningsfrihet, har de ideella föreningarna blivit ett landsomfattande forum för människor att slutas samman för gemensamma syften. De genomsyrar hela samhällslivet – från politiken, till idrott, körsång och fackföreningar. Ideella föreningar påverkar i stort sett hela den svenska befolkningen. ÄNon-profit associations are a fundamental part of Swedish society. Largely due to an extensive freedom of association, Sweden has become a society where non-profit associations thrive. Is a nationwide forum for individuals to unite around common purposes. Non-profit organisations permeate all aspects of social life—from politics to sports, choral singing, and labor unions. They impact virtually th

Investigating CSF flow in patients with idiopathic normal pressure hydrocephalus using phase-contrast 7T MRI

Idiopatisk normaltryckshydrocephalus (iNPH) är en neurologisk sjukdom som påverkar hjärnans vätskecirkulation och kan leda till symtom som gång- och balanssvårigheter, kognitiv nedsättning och urininkontinens. Sjukdomen drabbar omkring 1.5 % av 70-åringar, och prevalensen ökar med åldern. Det är en svårdiagnostiserad sjukdom där hjärnvätska (CSF) ansamlas i hjärnans hålrum, vilket påverkar hjärnanIntroduction: Idiopathic normal pressure hydrocephalus (iNPH) is a treatable but largely underdiagnosed neurological condition affecting the elderly population. It is characterised by gait and cognitive impairment, as well as urinary incontinence. For the most part, it is diagnosed via imaging and clinical assessments. Abnormalities in cerebrospinal (CSF) flow in the cerebral aqueduct have been li

Swedish State Monopolies and their Compatibility with EC Law

The principal rule of the common market is that goods and services are able to move freely across the borders of Member States. State monopolies in control of supply and demand are, therefore, only under exceptional circumstances compatible with the conditions of the common market. The compatibility of Swedish State monopolies with EC law is a controversial matter. The case-law of the ECJ lets us

Technology Scouting in China: For identifying cost reduction and opportunities for innovation

Title: Technology Scouting in China For identifying cost reduction and opportunities for innovation Authors: Tor Blomdell and Oscar Örtendahl Tutors: Bengt Järrehult – Adjunct professor, Department of Packaging Logistic, Lund Institute of Technology Sigvald Harryson – Associate professor, Institute of Economic Research, Lund School of Economics and Management Lars Sickert - Technology Analyst, Tec

Association of Maternal SARS-CoV-2 Infection in Pregnancy With Neonatal Outcomes

IMPORTANCE: The outcomes of newborn infants of women testing positive for SARS-CoV-2 in pregnancy is unclear.OBJECTIVE: To evaluate neonatal outcomes in relation to maternal SARS-CoV-2 test positivity in pregnancy.DESIGN, SETTING, AND PARTICIPANTS: Nationwide, prospective cohort study based on linkage of the Swedish Pregnancy Register, the Neonatal Quality Register, and the Register for Communicab

Bristande information och samtycke - brister lagen? Patientens ställning ur ett ersättningsperspektiv

A patient who comes up against a bodily injury due to medical care, may be entitled to compensation - but the legal requirements in order to recieve compensation diversifies with the cause of damage. PSL comprises certain circumstances and identifies situations under which a patient may be entitled to insurance based indemnification. SKL is generally applicable on questions of pain-and-suffering a