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Sphingosine-1-Phosphate, a Marker of Endothelial Injury and Disease Severity in Preeclampsia

BACKGROUND: Preeclampsia is a hypertensive pregnancy disorder marked by endothelial damage. Healthy endothelium is covered by a protective glycocalyx layer, which, when degraded, releases detectable products into the blood. Sphingosine-1phosphate (S1P) is a cardiovascular biomarker involved in glycocalyx preservation, linked to placentation and preeclampsia development. The study aimed to test the

Plasma endostatin at intensive care admission is independently associated with acute kidney injury, dialysis, and mortality in COVID-19

BackgroundCritical COVID-19 is associated with high mortality, and acute kidney injury (AKI) is common. Endostatin has emerged as a promising prognostic biomarker for predicting AKI and mortality in intensive care. This study aimed to investigate plasma endostatin at intensive care unit (ICU) admission as a biomarker for AKI, renal replacement therapy (RRT), and 90-day mortality in COVID-19.Method

Healthcare data

In this chapter, we will discuss the limitations of police accident data and the added value of health data as a complementary source. Several types of health organisations exist that cover a certain severity of traffic casualties. A number of medical indicators will be discussed, as well as methods to estimate the true number of serious injuries and the completeness of the police reporting. For t

Effects of pre-treatment on characterization of microplastics in biosolids via optical photothermal infrared spectroscopy

Microplastics (MPs) in biosolids used as soil amendments are of growing concern. The purpose of this study was to improve the characterization of MPs in complex biosolid matrices by optimizing sample preparation for morphological and chemical analyses with different spectroscopic techniques. We compared extraction procedures involving Fenton oxidation (F), Fenton plus sodium dodecyl sulfate (SDS),

Volcanic temperature changes modulated volatile release and climate fluctuations at the end-Triassic mass extinction

Emplacement of the Central Atlantic Magmatic Province (CAMP) is thought to have triggered global environmental changes and the end-Triassic mass extinction (ETE). However, the mechanisms linking volcanism and environmental change are unclear. Here we provide new insight into these linkages by measuring the abundance of both sedimentary five- to six-ring polycyclic aromatic hydrocarbons (PAHs) and

Predicting intensive care need in women with preeclampsia using machine learning–a pilot study

Background: Predicting severe preeclampsia with need for intensive care is challenging. To better predict high-risk pregnancies to prevent adverse outcomes such as eclampsia is still an unmet need worldwide. In this study we aimed to develop a prediction model for severe outcomes using routine biomarkers and clinical characteristics. Methods: We used machine learning models based on data from an i

Sports-Related Traumatic Brain Injury

The speed and intensity of modern sports puts the athlete at risk for impacts to the head, or to the body when the impact force is transmitted to the head. Rapid head rotation caused by these impact forces may lead to a sports-related concussion (SRC), defined as a mild traumatic brain injury, typically resulting in short-lived disturbance of the central nervous system function. The diagnosis of S

The first comprehensive population size estimations for the highly endangered largest diving beetle Dytiscus latissimus in Europe

Dytiscus latissimus (Coleoptera Dytiscidae) is an endangered diving beetle throughout its range. It is one of the two species of Dytiscidae listed in Annex II of the Habitats Directive, IUCN red list and in many national level legislations and therefore strictly protected. The conservation of endangered species first of all requires an assessment of their population size. Until now, a method has n

Host shift and natural long-distance dispersal to an oceanic island of a host-specific parasite

Parasite dispersal and host-switching may be better understood by knowing when they occurred. We estimated when the ancestor of a parasite of great reed warblers (Acrocephalus arundinaceus) dispersed to the Seychelles and began infecting the endemic Seychelles warbler (A. sechellensis). We used mitochondrial genomes and published molecular divergence rates to estimate the date of divergence betwee

A critical typology of "good place branding" : Lessons from place-branding expertise

Place branding is defined as “the development of brands for geographic locationswith the aim of triggering positive associations about the area and distinguishinga place from other places” (Stevens et al., 2020, p. 752). Like all occupations,place branding is organised by discourses, or talk, that determine best practices andnorms about what constitutes expertise (Loacker and Sullivan, 2016). Expl

Formation and photoluminescence of Ge and Si nanoparticles encapsulated in oxide layers

Ge and Si semiconductor nanoparticles encapsulated in oxide layers were prepared by the inert gas condensation method. High-resolution electron microscopy and energy dispersive X-ray spectrometry showed the formation of the core-shell structures with a size below 10 nm. The optical absorption spectra of Ge showed the band edges at higher energy compared to the ordinary Ge element. Photoluminescenc

Digitalization: A Potential Tool for Sustainable Consumption?

Given the outsized impact that digitalization has had on consumption over the last two decades, the lack of academic interest in sustainable consumption is noteworthy. In this book chapter, we set the scene for the fundamentally important discussion about how digitalization affects consumption. We ask whether digitalization is a positive or a negative force for shaping consumption levels and patte

English Medium Instruction in Multilingual and Multicultural Universities : Academics’ Voices from the Northern European Context

English Medium Instruction in Multilingual and Multicultural Universities analyses the issues related to EMI at both a local and international level and provides a broad perspective on this topic. Drawing on field studies from a Northern European context and based primarily on research carried out at the University of Copenhagen, this book:• introduces a topical global issue that is central to the

From Great Novels to Jantsch/Prigogine, Ken Wilber and Stephen Wolfram. Erland Lageroth's Homepage

"Search is our greatest adventure" (Rolf Edberg). Join me in this adventure and experience the same joy, enlightment, and insight that this journey of discoveries during 50 years has given me! The journey, way, narrative begins with criticism of fiction and goes via rethinking of literary research, humanities, and natural science to the discovery of a "humanistic" natural science, a "world philos

Perivascular cells expressing annexin A5 define a novel mesenchymal stem cell-like population with the capacity to differentiate into multiple mesenchymal lineages

The annexin A5 gene (Anxa5) was recently found to be expressed in the developing and adult vascular system as well as the skeletal system. In this paper, the expression of an Anxa5-lacZ fusion gene was used to define the onset of expression in the vasculature and to characterize these Anxa5-lacZ-expressing vasculature-associated cells. After blastocyst implantation, Anxa5-lacZ-positive cells were

Uppdatering av den vetenskapliga grunden för klimatarbetet. En översyn av naturvetenskapliga aspekter

Sammanfattning Det naturvetenskapliga kunskapsläget om klimatförändringarna förbättrats ständigt genom forskningen om klimatsystemet, klimatpåverkan, klimatets variationer och förändringar samt klimateffekter. Kunskapsläget är väletablerat när det gäller den grundläggande fysiken bakom växthuseffekten, liksom att genomsnittstemperaturen vid jordytan stigit de senaste femtio åren. Det är också my