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Ärftlighetsforskningens gränser : Individer och institutioner i framväxten av svensk genetik

Popular Abstract in Swedish Den moderna genetiken tar sin början kring sekelskiftet 1900 då de mendelska lagarna återupptäcktes. Den tidiga utvecklingen skedde i många länder i nära anslutning till den praktiska växtförädlingen, så även i Sverige där det redan fanns en framgångsrik växtförädling genom Sveriges utsädesförenings verksamhet i Svalöf. Här introducerade botanisten Herman Nilsson-Ehle mIn the first part of the 20th century genetics developed into an important research field. The aim of this study is to follow and analyse the transformation of genetics from its origin within an agricultural context to an academic discipline in Sweden (ca. 1900-1960). Mendelism was introduced as a methodology in plant breeding at the plant breeding station in Svalöf during the first decade of the

Om social sårbarhet i samband med extraordinära händelser - en intervjustudie i 12 kommuner

The aim of this report is to study how the authorities in twelve Swedish municipalities consider social vulnerability in disasters. The study is based on telephone interviews with ten officials responsible for safety and risk analysis and with ten officials responsible for social and psychological support after disasters. Three group interviews about the support for affected citizens after the sto

Oil Spills in Öresund - Hazardous Events, Causes and Claims

Öresund is one of the areas in the world with most ship movements. More than 40,000 ships pass through the sound in the direction north-south or the opposite every year. Other ships/ferries frequently cross the sound in the direction east-west or west-east. The ships carry goods and/or passengers in huge volumes. Since Öresund is a quite narrow sound with a difficult navigation situation, many ris

Review of Computer Based Methods for Modeling and Simulating Critical infrastructures as Socio-Technical Systems

The paper presents a review of the scientific literature on computer modeling of socio-technical systems. The aim is to briefly review and discuss modeling approaches that are suitable for the simulation of socio-technical systems, specifically in the context of risk and vulnerability analysis of critical infrastructures. It is found that seven main socio-technical modeling approaches can be disce

On a Proposal for a Generic Package Development Process

Globalization pressures have today inflicted significant changes in the way industrial enterprises are organized and how products are developed, manufactured and brought to market. A common denominator in many of these enterprises is the utilization of an organizational structure based on networks composed of divisions and supplier companies dispersed all over the world. ln these global enterprise

Efficient and Effective Learning for Safety from Incidents

Learning from incidents is important for improving safety. Many companies spend a great deal of time and money on such learning procedures. The objectives of this paper are to present some early results from a project aimed at revealing weaknesses in the procedures for learning from incidents and to discuss improvements in these procedures, especially in chemical process industries. The empirical

The effect of heat treatment on the soluble protein content of oats

The effect of heat treatment on the soluble protein content in oat groats (Kerstin commercial variety) was evaluated using asymmetric flow field-flow fractionation (AF4) in combination with online multiangle light scattering (MALS) and UV detection. The AF4 method was used to separate the monomeric proteins from globulin hexamer and aggregate proteins and beta-glucan polysaccharides in the soluble

Genome-wide association study on 13,167 individuals identifies regulators of hematopoietic stem and progenitor cell levels in human blood

Understanding how hematopoietic stem and progenitor cells (HSPCs) are regulated is of central importance for the development of new therapies for blood disorders and stem cell transplantation. To date, HSPC regulation has been extensively studied in vitro and in animal models, but less is known about the mechanisms in vivo in humans. Here, in a genome-wide association study on 13,167 individuals,

Stochastic model for COVID-19 in slums: interaction between biology and public policies

We present a mathematical model for the simulation of the development of an outbreak of COVID-19 in a slum area under different interventions. Instead of representing interventions as modulations of the parameters of a free running epidemic we introduce a model structure that accounts for the actions but does not assume the results. The disease is modelled in terms of the progression of viremia re

Coupled heat, mass and momentum transport in swelling cellulose based materials with application to retorting of paperboard packages

Understanding the complex interplay of mass transport, heat transport and deformation in swelling cellulose based materials is a challenging task. To aid in this endeavour a multiphysics model is developed within the mixture theory framework. The model is macroscopic and accounts for swelling, non-equilibrium mass exchange of water, elastic deformation and multiphase transport phenomena, where non

Label-free neuroblastoma cell separation from hematopoietic progenitor cell products using acoustophoresis - towards cell processing of complex biological samples

Processing of complex cell preparations such as blood and peripheral blood progenitor cell (PBPC) transplants using label-free technologies is challenging. Transplant-contaminating neuroblastoma cells (NBCs) can contribute to relapse, and we therefore aimed to provide proof-of-principle evidence that label-free acoustophoretic separation can be applied for diagnostic NBC enrichment and removal ("p

Measuring Niche-Associated Metabolic Activity in Planktonic and Biofilm Bacteria

Most pathobionts of the respiratory tract form biofilms during asymptomatic colonization to survive and persist in this niche. Environmental changes of the host niche, often resulting from infection with respiratory viruses, changes of the microbiota composition, or other host assaults, can result in biofilm dispersion and spread of bacteria to other host niches, resulting in infections, such as o

The Image is Openness, The Practice is Data

The paper argues for the importance of seeing just how we conceptualise digital phenomena in relation to how the regulatory discourses. The Internet used to be an “information superhighway”, a “cyberspace”, or a “world wide web” often described as an empowering structure, that now has transformed to be understood in terms of “layers”, a generator of big data for a number of “platform” ventures and

Extension of two large wastewater treatment plants in Stockholm using membrane technology

Like many other large cities, Stockholm is facing increased urbanization with densification of infrastructure as a result. At the same time, implementation of the Baltic Sea Action Plan and the EU Water Framework Directive is expected to result in more stringent effluent quality demands. The current situation gives rise to new challenges for the municipal wastewater treatment plants (WWTPs). This

Avoiding Acetate Accumulation in Escherichia coli Cultures Using Feedback Control of Glucose Feeding

An automated glucose feeding strategy that avoids acetate accumulationin cultivations of Escherichia coli is discussed. We havepreviously described how a probing technique makes it possible todetect and avoid overflow metabolism using a dissolved oxygen sensor.In this paper these ideas are extended with a safety net thatguarantees that aerobic conditions are maintained. The method isgenerally appl