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The c-Myc and MYCN oncogenes strongly induce cell proliferation. Although a limited series of cell cycle genes were found to be induced by the myc transcription factors, it is still unclear how they mediate the proliferative phenotype. We therefore analysed a neuroblastoma cell line with inducible MYCN expression. We found that all members of the minichromosome maintenance complex (MCM2 - 7) and M
Background: Abdominal surgery for cancer carries a high risk of venous thromboembolism, but the optimal duration of postoperative thromboprophylaxis is unknown. Methods: We conducted a double-blind, multicenter trial in which patients undergoing planned curative open surgery for abdominal or pelvic cancer received enoxaparin (40 mg subcutaneously) daily for 6 to 10 days and were then randomly assi
Activated Factor V (FVa) functions as a membrane-bound cofactor to the enzyme factor Xa (FXa) in the conversion of prothrombin to thrombin, increasing the catalytic efficiency of FXa by several orders of magnitude. To map regions on FVa that are important for binding of FXa, site-directed mutagenesis resulting in novel potential glycosylation sites on FV was used as strategy. The consensus sequenc
Background— Inflammation is an important pathophysiological feature of abdominal aortic aneurysms (AAA). Whether elevated levels of inflammation-sensitive plasma proteins (ISPs) predict the long-term risk of fatal or repaired AAA is largely unknown. Methods and Results— Five ISPs (fibrinogen, orosomucoid, {alpha}1-antitrypsin, haptoglobin, and ceruloplasmin) were measured in 6075 healthy men, mea
The emergence of levodopa (l-DOPA)-induced dyskinesia and motor fluctuations represents a major clinical problem in Parkinson's disease (PD). While it has been suggested that the daily dose of l-DOPA can play a critical role, the mechanisms linking l-DOPA dosage to the occurrence of motor complications have not yet been explored. Using an experimental model of PD we have recently demonstrated that
The present investigation addresses mazes in Swedish pre-school children with specific language impairment (SLI). Spontaneous speech samples from 10 Swedish children were collected and analysed with respect to amount of mazes and their distributional patterns. The subjects consisted of five children with SLI and five MLU (mean length of utterance) matched controls with normal grammatical developme
Helicobacter bilis DNA has been detected in human tissue and is a candidate for etiologic investigations on the causes of hepatic and biliary tract diseases, but reliable serologic tests need to be developed in order to pursue such investigations. The scope of this study was to assess the specificity of two assays for H. bilis immune response allowing for H. pylori, and their cross-reactivity in a
We calculate level densities and pairing gaps for an ultracold dilute gas of fermionic atoms in harmonic traps under the influence of mean field and anharmonic quartic trap potentials. Supershell nodes, which were found in Hartree-Fock calculations, are calculated analytically within periodic orbit theory as well as from WKB calculations. For attractive interactions, the underlying level densities
Electrochemical studies of laccases from basidiomycetes, i.e., Trametes hirsuta, Trametes ochracea, Coriolopsis fulvocinerea, Cerrena maxima, and Cerrena unicolor, have been performed. Direct (mediatorless) electrochemistry of laccases on graphite electrodes has been investigated with cyclic voltammetry, square wave voltammetry as well as potentiometry. For all mentioned high potential laccases di
A new Greenland Ice Core Chronology (GICC05) based on multi-parameter counting of annual layers has been obtained for the last 42 ka. Here we compare the glacial part of the new time scale, which is based entirely on records from the NorthGRIP ice core, to existing time scales and reference horizons covering the same period. These include the GRIP and NorthGRIP modelled time scales, the Meese-Sowe
The PID relay auto-tuner of Astrom–Hagglund is one of the simplest and most robust auto-tuning techniques for process controllers and has been successfully applied to industry for more than 15 years. This tuner is based on an approximate estimation of the critical point on the process frequency response from relay oscillations. Many developments have recently been reported to extend its applicatio
This study compares the performance of different models used to assess the local wind near-surface conditions at an agricultural site in Scania, southern Sweden. The methods are: (a) the WASP model (Wind Analysis and Application Program), (b) separate linear regressions of the two wind vector components, (c) a regression model based on vector correlation, and (d) linear regression of scalar wind.
Short-term cultures of samples from eight prophylactic mastectomies from five unrelated women who were genetically predisposed to breast cancer were analyzed cytogenetically. Clonal chromosome abnormalities were detected in five breasts. Three samples from two women had aberrations involving the short arm of chromosome 3, with a breakpoint in 3p14 in common. Three samples from three women had rear
Haptoglobin phenotypes have been shown in human medicine to be related to the prevalence of various diseases. Furthermore, abnormal glycosylation of haptoglobin has been reported as a consequence of liver disease, cancer and immunological disorders in man. To our knowledge, similar findings have not, so far, been reported in canine disease. The present paper describes a method for investigation of
Deficiencies in a tyrosine kinase, designated Btk, cause X-linked agammaglobulinemia (XLA) in man, a hereditary defect of B-cell differentiation. Mutations in the newly found PH domain located at the N-terminus of Btk have been shown to be the direct cause of XLA, and here two new mutations, T33P and V64F, are presented. Btk is thus far the only protein in which mutations of the PH domain have bee
PEG-12-acyloxystearates constitute a novel class of pharmaceutical solubilizers and are synthesized from polyethylene glycol and 12-hydroxystearic acid, which has been esterified with a second acyl chain. The hemolytic activity of these surfactants decreases drastically with increasing pendant acyloxy chain length, and surfactants with an acyloxy chain of 14 carbon atoms or more are essentially no
Research on short- and long-term response to trauma has been expanding over the past twenty years and has found new urgency in recent national and international events. As our understanding of risk factors for who will be most severely affected by trauma expands, what we don't know about the interactions between vulnerabilities and risk factors, peritraumatic and posttraumatic factors, physiologic
This paper presents a new constraint-driven method for fast identification of computational patterns that is a part of DURASE system (Generic Environment for Design and Utilization of Reconfigurable Application-Specific Processors Extensions). The patterns identified by our system form a base for application specific instruction selection and processor extension generation. Our method ide
