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The development of biotechnological products is becoming more and more expensive. One type of protein attracting a great deal of attention in the biopharmaceutical industry is antibodies, which was used in this work. The cost of producing antibodies is, however, high, mainly due to the downstream processing, which constitutes 50–80% of the total cost. This work describes model-based methods to des

The concept of personality is scrutinized as used both in common parlance and in more sophisticated frames of reference. Current multidimensional models are criticized for their reliance on self-descriptive questionnaires and for their lack of a hierarchical dimension, differentiating more or less decisive determinants of behavior. A possible psychoanalytic model is viewed with more benevolence bu

Modelling of 2D resistivity imaging was done in order to understand the principle resolution of the technique in different geological situations, and for assessing the behaviour of the interpretation methods under controlled circumstances. The Wenner array was used throughout. The results show that the 1D approximation only provides reasonable results in environments with very gradual lateral resi

We propose and investigate a unifying class of sparse random graph models, based on a hidden coloring of edge-vertex incidences, extending an existing approach, random graphs with a given degree distribution, in a way that admits a nontrivial correlation structure in the resulting graphs. The approach unifies a number of existing random graph ensembles within a common general formalism, and allows

The article discusses the sociocultural dimensions to the Chinese courtesy titles 'nüshi' (ladies) and 'xiansheng' (gentlemen).

This paper reflects how anti-islanding protection has developed with increasing DG penetration. Starting from a local issue it has developed to possibly affect system security. The focus here is on how islanding detection methods and anti-islanding protection settings relate to distribution level and TSO requirements. It is confirmed using field measurements and simulations that the most common pa

The reaction of [Co2{μ-C2(CO2Me)2}(CO)6] with the ligand diphenyl-2-thienylphosphine, PPh2(C4H3S), yields the complexes [Co2{μ-C2(CO2Me)2}(CO)5{PPh2(C4H3S)}] (1) and [Co2{μ-C2(CO2Me)2}(CO)4{PPh2(C4H3S)}2] (2). The related complex [Co3(μ3CMe)(CO)9] reacts with the same ligand to give [Co3(μ3-CMe)(CO)8{PPh2(C4H3S)}] (3) and [Co3(μ3-CMe)(CO)7{PPh2(C4H3S))2] (4). Thermolysis of 1 at 80°C leads to part

Antigenic variation of surface proteins allows microorganisms to evade the immune system of the infected host. This phenomenon represents an apparent paradox, because the variable protein must retain an important function, while its antigenic properties vary extensively. The surface associated M protein of Streptococcus pyogenes, a common human pathogen, exhibits antigenic variation due to an N-te

The risk assessment of pesticide residues in food is a key priority in the area of food safety. Most jurisdictions have implemented pre-marketing authorization processes, which are supported by prospective risk assessments. These prospective assessments estimate the expected residue levels in food combining results from residue trials, resembling the pesticide use patterns, with food con-sumption

Climate change is a pervasive threat to biodiversity. While range shifts are a known consequence of climate warming contributing to regional community change, less is known about how species’ positions shift within their climatic niches. Furthermore, whether the relative importance of different climatic variables prompting such shifts varies with changing climate remains unclear. Here we analysed

Aortic regurgitation (AR) following continuous flow left ventricular assist device implantation (cf-LVAD) may adversely impact outcomes. We aimed to assess the incidence and impact of progressive AR after cf-LVAD on prognosis, biomarkers, functional capacity and echocardiographic findings. In an analysis of the PCHF-VAD database encompassing 12 European heart failure centers, patients were dichoto

BackgroundCarotid artery disease is highly prevalent and a main cause of ischemic stroke and vascular dementia. There is a paucity of information on predictors of serious vascular events. Besides percentage diameter stenosis, international guidelines also recommend the evaluation of qualitative characteristics of carotid artery disease as a guide to treatment, but with no agreement on which qualit

This paper is an introduction to the topical collection dealing with the Post-glacial human subsistence and settlement patterns: insights from bones. The context of the Lateglacial and Early Holocene (ca. 16,000–6000 cal BP) in Europe offers the possibility to examine the response of terrestrial ecosystems to dramatic climatic changes and the evolution of subsistence among hunter-gatherers facing